Sequence information
Variant position: 173 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
PGTRVRAMAIYKQSQHMTEV
V RRCPHHERCSDSDGLAPPQH
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PGTRVRAMAIYKQSQHMTEVV RRCPHHERCSD-SDGLAPPQH
PNTCVRAMAIYKKSEFVTEVV RRCPHHERCSDSSDGLAPPQ
Rhesus macaque PGSRVRAMAIYKQSQHMTEVV RRCPHHERCSD-SDGLAPPQ
Mouse AGSRVRAMAIYKKSQHMTEVV RRCPHHERCSD-GDGLAPPQ
Rat PGTRVRAMAIYKKSQHMTEVV RRCPHHERCSD-GDGLAPPQ
Pig PGTRVRAMAIYKKSEYMTEVV RRCPHHERSSDYSDGLAPPQ
Bovine PGTRVRAMAIYKKLEHMTEVV RRCPHHERSSDYSDGLAPPQ
Rabbit PGTRVRAMAIYKKSQHMTEVV RRCPHHERCSD-SDGLAPPQ
Sheep PGTRVRAMAIYKKLEHMTEVV RRSPHHERSSDYSDGLAPPQ
Cat PGTCVRAMAIYKKSEFMTEVV RRCPHHERCPDSSDGLAPPQ
Chicken PGSSLRAVAVYKKSEHVAEVV RRCPHHERCGGGTDGLAPAQ
Xenopus laevis RGSILRATAVYKKSEHVAEVV KRCPHHERSVEPGEDAAPPS
Zebrafish QGSVVRATAIYKKSEHVAEVV RRCPHHERTPD-GDNLAPAG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 393
Cellular tumor antigen p53
DNA binding
102 – 292
Region
1 – 320
Interaction with CCAR2
Region
100 – 370
Interaction with HIPK1
Region
100 – 300
Required for interaction with ZNF385A
Region
113 – 236
Required for interaction with FBXO42
Region
116 – 292
Interaction with AXIN1
Metal binding
176 – 176
Zinc
Metal binding
179 – 179
Zinc
Modified residue
183 – 183
Phosphoserine; by AURKB
Mutagenesis
183 – 183
S -> A. Abolishes strongly phosphorylation.
Mutagenesis
183 – 183
S -> E. Inhibits slightly its transcriptional activity.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.