Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Arg175Pro

Cellular tumor antigen p53
Gene: TP53
Feedback?
Variant information Variant position: help 175
Type of variant: help US
Residue change: help From Arginine (R) to Proline (P) at position 175 (R175P, p.Arg175Pro).
Physico-chemical properties: help Change from large size and basic (R) to medium size and hydrophobic (P)
BLOSUM score: help -2
Variant description: help In sporadic cancers; somatic mutation.


Sequence information Variant position: help 175
Protein sequence length: help 393
Location on the sequence: help TRVRAMAIYKQSQHMTEVVR R CPHHERCSDSDGLAPPQHLI
Residue conservation: help 
Human                         TRVRAMAIYKQSQHMTEVVRRCPHHERCSD-SDGLAPPQHLI

                              TCVRAMAIYKKSEFVTEVVRRCPHHERCSDSSDGLAPPQHL

Rhesus macaque                SRVRAMAIYKQSQHMTEVVRRCPHHERCSD-SDGLAPPQHL

Mouse                         SRVRAMAIYKKSQHMTEVVRRCPHHERCSD-GDGLAPPQHL

Rat                           TRVRAMAIYKKSQHMTEVVRRCPHHERCSD-GDGLAPPQHL

Pig                           TRVRAMAIYKKSEYMTEVVRRCPHHERSSDYSDGLAPPQHL

Bovine                        TRVRAMAIYKKLEHMTEVVRRCPHHERSSDYSDGLAPPQHL

Rabbit                        TRVRAMAIYKKSQHMTEVVRRCPHHERCSD-SDGLAPPQHL

Sheep                         TRVRAMAIYKKLEHMTEVVRRSPHHERSSDYSDGLAPPQHL

Cat                           TCVRAMAIYKKSEFMTEVVRRCPHHERCPDSSDGLAPPQHL

Chicken                       SSLRAVAVYKKSEHVAEVVRRCPHHERCGGGTDGLAPAQHL

Xenopus laevis                SILRATAVYKKSEHVAEVVKRCPHHERSVEPGEDAAPPSHL

Zebrafish                     SVVRATAIYKKSEHVAEVVRRCPHHERTPD-GDNLAPAGHL
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Binding site 176 – 176
Binding site 179 – 179
Modified residue 183 – 183 Phosphoserine; by AURKB
Mutagenesis 183 – 183 S -> A. Abolishes strongly phosphorylation.
Mutagenesis 183 – 183 S -> E. Inhibits slightly its transcriptional activity.



Literature citations
Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.
Das S.; Raj L.; Zhao B.; Kimura Y.; Bernstein A.; Aaronson S.A.; Lee S.W.;
Cell 130:624-637(2007)
Cited for: INTERACTION WITH ZNF385A; CHARACTERIZATION OF VARIANTS ALA-143; HIS-175 AND PRO-175;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.