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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Arg181Leu

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 181
Type of variant: help US
Residue change: help From Arginine (R) to Leucine (L) at position 181 (R181L, p.Arg181Leu).
Physico-chemical properties: help Change from large size and basic (R) to medium size and hydrophobic (L)
BLOSUM score: help -2
Variant description: help In a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 181
Protein sequence length: help 393
Location on the sequence: help AIYKQSQHMTEVVRRCPHHE R CSDSDGLAPPQHLIRVEGNL
Residue conservation: help 
Human                         AIYKQSQHMTEVVRRCPHHERCSD-SDGLAPPQHLIRVEGNL

                              AIYKKSEFVTEVVRRCPHHERCSDSSDGLAPPQHLIRVEGN

Rhesus macaque                AIYKQSQHMTEVVRRCPHHERCSD-SDGLAPPQHLIRVEGN

Mouse                         AIYKKSQHMTEVVRRCPHHERCSD-GDGLAPPQHLIRVEGN

Rat                           AIYKKSQHMTEVVRRCPHHERCSD-GDGLAPPQHLIRVEGN

Pig                           AIYKKSEYMTEVVRRCPHHERSSDYSDGLAPPQHLIRVEGN

Bovine                        AIYKKLEHMTEVVRRCPHHERSSDYSDGLAPPQHLIRVEGN

Rabbit                        AIYKKSQHMTEVVRRCPHHERCSD-SDGLAPPQHLIRVEGN

Sheep                         AIYKKLEHMTEVVRRSPHHERSSDYSDGLAPPQHLIRVEGN

Cat                           AIYKKSEFMTEVVRRCPHHERCPDSSDGLAPPQHLIRVEGN

Chicken                       AVYKKSEHVAEVVRRCPHHERCGGGTDGLAPAQHLIRVEGN

Xenopus laevis                AVYKKSEHVAEVVKRCPHHERSVEPGEDAAPPSHLMRVEGN

Zebrafish                     AIYKKSEHVAEVVRRCPHHERTPD-GDNLAPAGHLIRVEGN
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Binding site 176 – 176
Binding site 179 – 179
Modified residue 183 – 183 Phosphoserine; by AURKB
Mutagenesis 183 – 183 S -> A. Abolishes strongly phosphorylation.
Mutagenesis 183 – 183 S -> E. Inhibits slightly its transcriptional activity.
Beta strand 181 – 183



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.