Sequence information
Variant position: 237 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
VVPYEPPEVGSDCTTIHYNY
M CNSSCMGGMNRRPILTIITL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VVPYEPPEVGSDCTTIHYNYM CNSSCMGGMNRRPILTIITL
VVPYEPPEVGSDYTTIHYNYM CNSSCMGGMNRRPILTIITL
Rhesus macaque VVPYEPPEVGSDCTTIHYNYM CNSSCMGGMNRRPILTIITL
Mouse VVPYEPPEAGSEYTTIHYKYM CNSSCMGGMNRRPILTIITL
Rat VVPYEPPEVGSDYTTIHYKYM CNSSCMGGMNRRPILTIITL
Pig VVPYEPPEVGSDCTTIHYNFM CNSSCMGGMNRRPILTIITL
Bovine VVPYESPEIDSECTTIHYNFM CNSSCMGGMNRRPILTIITL
Rabbit VVPYEPPEVGSDCTTIHYNYM CNSSCMGGMNRRPILTIITL
Sheep VVPYESPEIESECTTIHYNFM CNSSCMGGMNRRPILTIITL
Cat VVPYEPPEVGSDCTTIHYNFM CNSSCMGGMNRRPIITIITL
Chicken VVPYEPPEVGSDCTTVLYNFM CNSSCMGGMNRRPILTILTL
Xenopus laevis CVPYEGPQVGTECTTVLYNYM CNSSCMGGMNRRPILTIITL
Zebrafish FVPYEAPQLGAEWTTVLLNYM CNSSCMGGMNRRPILTIITL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Literature citations
Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3.
Guan Y.; Huang D.; Chen F.; Gao C.; Tao T.; Shi H.; Zhao S.; Liao Z.; Lo L.J.; Wang Y.; Chen J.; Peng J.;
PLoS Biol. 14:e1002555-e1002555(2016)
Cited for: CHARACTERIZATION OF VARIANTS VAL-138; HIS-175; ILE-237; TRP-248 AND PRO-273;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.