Variant position: 252 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IHYNYMCNSSCMGGMNRRPI LTIITLEDSSGNLLGRNSFEV
Rhesus macaque IHYNYMCNSSCMGGMNRRPI LTIITLEDSSGNLLGRNSFEV
Mouse IHYKYMCNSSCMGGMNRRPI LTIITLEDSSGNLLGRDSFEV
Rat IHYKYMCNSSCMGGMNRRPI LTIITLEDSSGNLLGRDSFEV
Pig IHYNFMCNSSCMGGMNRRPI LTIITLEDASGNLLGRNSFEV
Bovine IHYNFMCNSSCMGGMNRRPI LTIITLEDSCGNLLGRNSFEV
Rabbit IHYNYMCNSSCMGGMNRRPI LTIITLEDSSGNLLGRNSFEV
Sheep IHYNFMCNSSCMGGMNRRPI LTIITLEDSRGNLLGRSSFEV
Cat IHYNFMCNSSCMGGMNRRPI ITIITLEDSNGKLLGRNSFEV
Chicken VLYNFMCNSSCMGGMNRRPI LTILTLEGPGGQLLGRRCFEV
Xenopus laevis VLYNYMCNSSCMGGMNRRPI LTIITLETPQGLLLGRRCFEV
Zebrafish VLLNYMCNSSCMGGMNRRPI LTIITLETQEGQLLGRRSFEV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 393 Cellular tumor antigen p53
102 – 292
1 – 320 Interaction with CCAR2
100 – 370 Interaction with HIPK1
100 – 300 Required for interaction with ZNF385A
116 – 292 Interaction with AXIN1
238 – 238 Zinc
242 – 242 Zinc
269 – 269 Phosphoserine; by AURKB
248 – 248 R -> S. Does not induce SNAI1 degradation.
269 – 269 S -> A. Abolishes phosphorylation.
269 – 269 S -> E. Inhibits strongly its transcriptional activity.
251 – 258
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.
Malkin D.; Li F.P.; Strong L.C.; Fraumeni J.F. Jr.; Nelson C.E.; Kim D.H.; Kassel J.; Gryka M.A.; Bischoff F.Z.; Tainsky M.A.; Friend S.H.;
Cited for: VARIANTS LFS CYS-245; TRP-248; PRO-252 AND LYS-258;
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