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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Glu258Lys

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 258
Type of variant: help LP/P [Disclaimer]
Residue change: help From Glutamate (E) to Lysine (K) at position 258 (E258K, p.Glu258Lys).
Physico-chemical properties: help Change from medium size and acidic (E) to large size and basic (K)
BLOSUM score: help 1
Variant description: help In LFS; germline mutation and in sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 258
Protein sequence length: help 393
Location on the sequence: help CNSSCMGGMNRRPILTIITL E DSSGNLLGRNSFEVRVCACP
Residue conservation: help
Human                         CNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACP

                              CNSSCMGGMNRRPILTIITLEDSSGNVLGRNSFEVRVCACP

Rhesus macaque                CNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACP

Mouse                         CNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACP

Rat                           CNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACP

Pig                           CNSSCMGGMNRRPILTIITLEDASGNLLGRNSFEVRVCACP

Bovine                        CNSSCMGGMNRRPILTIITLEDSCGNLLGRNSFEVRVCACP

Rabbit                        CNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACP

Sheep                         CNSSCMGGMNRRPILTIITLEDSRGNLLGRSSFEVRVCACP

Cat                           CNSSCMGGMNRRPIITIITLEDSNGKLLGRNSFEVRVCACP

Chicken                       CNSSCMGGMNRRPILTILTLEGPGGQLLGRRCFEVRVCACP

Xenopus laevis                CNSSCMGGMNRRPILTIITLETPQGLLLGRRCFEVRVCACP

Zebrafish                     CNSSCMGGMNRRPILTIITLETQEGQLLGRRSFEVRVCACP

Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 116 – 292 Interaction with AXIN1
Region 256 – 294 Interaction with E4F1
Binding site 238 – 238
Binding site 242 – 242
Modified residue 269 – 269 Phosphoserine; by AURKB
Mutagenesis 248 – 248 R -> S. Does not induce SNAI1 degradation.
Mutagenesis 269 – 269 S -> A. Abolishes phosphorylation.
Mutagenesis 269 – 269 S -> E. Inhibits strongly its transcriptional activity.
Beta strand 251 – 258



Literature citations
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.
Malkin D.; Li F.P.; Strong L.C.; Fraumeni J.F. Jr.; Nelson C.E.; Kim D.H.; Kassel J.; Gryka M.A.; Bischoff F.Z.; Tainsky M.A.; Friend S.H.;
Science 250:1233-1238(1990)
Cited for: VARIANTS LFS CYS-245; TRP-248; PRO-252 AND LYS-258;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.