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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Pro278Ser

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 278
Type of variant: help LP/P [Disclaimer]
Residue change: help From Proline (P) to Serine (S) at position 278 (P278S, p.Pro278Ser).
Physico-chemical properties: help Change from medium size and hydrophobic (P) to small size and polar (S)
BLOSUM score: help -1
Variant description: help In LFS; germline mutation and in sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 278
Protein sequence length: help 393
Location on the sequence: help EDSSGNLLGRNSFEVRVCAC P GRDRRTEEENLRKKGEPHHE
Residue conservation: help 
Human                         EDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPH--HE

                              EDSSGNVLGRNSFEVRVCACPGRDRRTEEENFHKKGEPC--

Rhesus macaque                EDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKKGEPC--

Mouse                         EDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLC--

Rat                           EDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEEHC--

Pig                           EDASGNLLGRNSFEVRVCACPGRDRRTEEENFLKKGQSC--

Bovine                        EDSCGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGQSC--

Rabbit                        EDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKKGEPC--

Sheep                         EDSRGNLLGRSSFEVRVCACPGRDRRTEEENFRKKGQSC--

Cat                           EDSNGKLLGRNSFEVRVCACPGRDRRTEEENFRKKGEPC--

Chicken                       EGPGGQLLGRRCFEVRVCACPGRDRKIEEENFRKRGGAG--

Xenopus laevis                ETPQGLLLGRRCFEVRVCACPGRDRRTEEDNYTKKRGLK--

Zebrafish                     ETQEGQLLGRRSFEVRVCACPGRDRKTEESNFKKDQETKTM
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 116 – 292 Interaction with AXIN1
Region 256 – 294 Interaction with E4F1
Region 273 – 280 Interaction with DNA
Modified residue 269 – 269 Phosphoserine; by AURKB
Modified residue 284 – 284 Phosphothreonine; by AURKB
Cross 291 – 291 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross 292 – 292 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Mutagenesis 269 – 269 S -> A. Abolishes phosphorylation.
Mutagenesis 269 – 269 S -> E. Inhibits strongly its transcriptional activity.
Mutagenesis 284 – 284 T -> E. Inhibits strongly its transcriptional activity.
Helix 278 – 287



Literature citations
Frequent mutation of the p53 gene in human esophageal cancer.
Hollstein M.C.; Metcalf R.A.; Welsh J.A.; Montesano R.; Harris C.C.;
Proc. Natl. Acad. Sci. U.S.A. 87:9958-9961(1990)
Cited for: VARIANTS SPORADIC CANCER VAL-154; VAL-245; GLN-248; LEU-278 AND SER-278; Detection of p53 gene mutations in oral squamous cell carcinomas of a black African population sample.
van Rensburg E.J.; Engelbrecht S.; van Heerden W.F.P.; Kotze M.J.; Raubenheimer E.J.;
Hum. Mutat. 11:39-44(1998)
Cited for: VARIANTS SER-152; ILE-169; PHE-176; THR-195; CYS-220; ILE-230; CYS-273 AND SER-278; The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Science 314:268-274(2006)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-134; PHE-157; CYS-163; HIS-175; ARG-177; ARG-193; PRO-213; PHE-241; PHE-242; GLN-248; TRP-248; SER-249; TRP-267; LYS-271; CYS-273; HIS-273; LEU-273; SER-278; ILE-280 AND HIS-281;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.