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UniProtKB/Swiss-Prot P04637: Variant p.Arg283Cys

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 283
Type of variant: help LP/P [Disclaimer]
Residue change: help From Arginine (R) to Cysteine (C) at position 283 (R283C, p.Arg283Cys).
Physico-chemical properties: help Change from large size and basic (R) to medium size and polar (C)
BLOSUM score: help -3
Variant description: help In LFS; germline mutation and in sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 283
Protein sequence length: help 393
Location on the sequence: help NLLGRNSFEVRVCACPGRDR R TEEENLRKKGEPHHELPPGS
Residue conservation: help 
Human                         NLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPH--HELPPGS

                              NVLGRNSFEVRVCACPGRDRRTEEENFHKKGEPC--PEPPP

Rhesus macaque                NLLGRNSFEVRVCACPGRDRRTEEENFRKKGEPC--HQLPP

Mouse                         NLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLC--PELPP

Rat                           NLLGRDSFEVRVCACPGRDRRTEEENFRKKEEHC--PELPP

Pig                           NLLGRNSFEVRVCACPGRDRRTEEENFLKKGQSC--PEPPP

Bovine                        NLLGRNSFEVRVCACPGRDRRTEEENLRKKGQSC--PEPPP

Rabbit                        NLLGRNSFEVRVCACPGRDRRTEEENFRKKGEPC--PELPP

Sheep                         NLLGRSSFEVRVCACPGRDRRTEEENFRKKGQSC--PEPPP

Cat                           KLLGRNSFEVRVCACPGRDRRTEEENFRKKGEPC--PEPPP

Chicken                       QLLGRRCFEVRVCACPGRDRKIEEENFRKRGGAG-------

Xenopus laevis                LLLGRRCFEVRVCACPGRDRRTEEDNYTKKRGLK-----PS

Zebrafish                     QLLGRRSFEVRVCACPGRDRKTEESNFKKDQETKTMAKTTT
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 116 – 292 Interaction with AXIN1
Region 256 – 294 Interaction with E4F1
Region 282 – 325 Disordered
Compositional bias 282 – 299 Basic and acidic residues
Modified residue 269 – 269 Phosphoserine; by AURKB
Modified residue 284 – 284 Phosphothreonine; by AURKB
Cross 291 – 291 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross 292 – 292 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Mutagenesis 269 – 269 S -> A. Abolishes phosphorylation.
Mutagenesis 269 – 269 S -> E. Inhibits strongly its transcriptional activity.
Mutagenesis 284 – 284 T -> E. Inhibits strongly its transcriptional activity.
Helix 278 – 287



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.