Sequence information
Variant position: 325 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
KRALPNNTSSSPQPKKKPLD
G EYFTLQIRGRERFEMFRELN
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KRALPNNTS-SSPQPK----KK----PLDG EYFTLQIRGRERFEMFRELN
KRALPPSTS-SSPPQK----KK----PLDG EYFTLQIRGRE
Rhesus macaque KRALPNNTS-SSPQPK----KK----PLDG EYFTLQIRGRE
Mouse KRALPTCTS-ASPPQK----KK----PLDG EYFTLKIRGRK
Rat KRALPTSTS-SSPQQK----KK----PLDG EYFTLKIRGRE
Pig KRALPTSTS-SSPVQK----KK----PLDG EYFTLQIRGRE
Bovine KRALPTNTS-SSPQPK----KK----PLDG EYFTLQIRGFK
Rabbit KRALPTTTTDSSPQTK----KK----PLDG EYFILKIRGRE
Sheep KRALPSSTS-SSPQQK----KK----PLDG EYFTLQIRGRK
Cat KRALPPSTS-STPPQK----KK----PLDG EYFTLQIRGRE
Chicken KRAMSPPTE-APEPPK----KR--VLNPDN EIFYLQVRGRR
Xenopus laevis ELAHPPSSE--PPLPK----KRLVVVDDDE EIFTLRIKGRS
Zebrafish RSLVKESSS-ATLRPEGSKKAK--GSSSDE EIFTLQVRGRE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 393
Cellular tumor antigen p53
Region
100 – 370
Interaction with HIPK1
Region
300 – 393
Interaction with CARM1
Region
319 – 360
Interaction with HIPK2
Region
325 – 356
Oligomerization
Modified residue
305 – 305
N6-acetyllysine
Modified residue
315 – 315
Phosphoserine; by AURKA, CDK1 and CDK2
Modified residue
321 – 321
N6-acetyllysine
Mutagenesis
319 – 319
K -> A. Loss of nuclear localization; when associated with A-320 and A-321.
Mutagenesis
320 – 320
K -> A. Loss of nuclear localization; when associated with A-319 and A-321.
Mutagenesis
321 – 321
K -> A. Loss of nuclear localization; when associated with A-319 and A-320.
Literature citations
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
Malkin D.; Jolly K.W.; Barbier N.; Look A.T.; Friend S.H.; Gebhardt M.C.; Andersen T.I.; Boerresen A.-L.; Li F.P.; Garber J.; Strong L.C.;
N. Engl. J. Med. 326:1309-1315(1992)
Cited for: VARIANTS LFS HIS-273 AND VAL-325;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.