Variant position: 325 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KRALPNNTS-SSPQPK----KK----PLD GEYFTLQIRGRERFEMFRELN
Rhesus macaque KRALPNNTS-SSPQPK----KK----PLD GEYFTLQIRGRE
Mouse KRALPTCTS-ASPPQK----KK----PLD GEYFTLKIRGRK
Rat KRALPTSTS-SSPQQK----KK----PLD GEYFTLKIRGRE
Pig KRALPTSTS-SSPVQK----KK----PLD GEYFTLQIRGRE
Bovine KRALPTNTS-SSPQPK----KK----PLD GEYFTLQIRGFK
Rabbit KRALPTTTTDSSPQTK----KK----PLD GEYFILKIRGRE
Sheep KRALPSSTS-SSPQQK----KK----PLD GEYFTLQIRGRK
Cat KRALPPSTS-STPPQK----KK----PLD GEYFTLQIRGRE
Chicken KRAMSPPTE-APEPPK----KR--VLNPD NEIFYLQVRGRR
Xenopus laevis ELAHPPSSE--PPLPK----KRLVVVDDD EEIFTLRIKGRS
Zebrafish RSLVKESSS-ATLRPEGSKKAK--GSSSD EEIFTLQVRGRE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 393 Cellular tumor antigen p53
100 – 370 Interaction with HIPK1
300 – 393 Interaction with CARM1
319 – 360 Interaction with HIPK2
325 – 356 Oligomerization
305 – 305 N6-acetyllysine
315 – 315 Phosphoserine; by AURKA, CDK1 and CDK2
321 – 321 N6-acetyllysine
319 – 319 K -> A. Loss of nuclear localization; when associated with A-320 and A-321.
320 – 320 K -> A. Loss of nuclear localization; when associated with A-319 and A-321.
321 – 321 K -> A. Loss of nuclear localization; when associated with A-319 and A-320.
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
Malkin D.; Jolly K.W.; Barbier N.; Look A.T.; Friend S.H.; Gebhardt M.C.; Andersen T.I.; Boerresen A.-L.; Li F.P.; Garber J.; Strong L.C.;
N. Engl. J. Med. 326:1309-1315(1992)
Cited for: VARIANTS LFS HIS-273 AND VAL-325;
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