Variant position: 148 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 354 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LFVVNHPEFKNTVEIFKFEE AENSLLHLKTVKHELLPSVND
Mouse LFVVNHPQFKSTVEIFKFQE EENSLLHLKTIKHELLPSVND
Rat LFVVNHPEFKNTVEIFKFQE EENSLLHLKTIKHELLPSVND
Bovine LFVVNHPEFKNTVEIFKFEE EENSLLHLKTIKHELLPSVND
Chicken LFVVNHPHQKSTVELFKFME DDNSLVHLKTIRHDLLTSVND
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 354 Serum paraoxonase/arylesterase 2
167 – 167 Calcium 1; catalytic
168 – 168 Calcium 2
42 – 352
Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence.
Mochizuki H.; Scherer S.W.; Xi T.; Nickle D.C.; Majer M.; Huizenga J.J.; Tsui L.-C.; Prochazka M.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 50-67; ALTERNATIVE SPLICING; VARIANT GLY-148;
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS GLY-148 AND LEU-172;
Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus.
Hegele R.A.; Connelly P.W.; Scherer S.W.; Hanley A.J.G.; Harris S.B.; Tsui L.-C.; Zinman B.;
J. Clin. Endocrinol. Metab. 82:3373-3377(1997)
Cited for: VARIANT GLY-148;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.