Variant position: 151 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 780 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EWGSLLEELVAEGKISETTA RTYSHLNIAGLVGSIDNDFCG
Mouse EWGSLLEELVKEGKISESTA QNYAHLTIAGLVGSIDNDFCG
Rat EWGSLLEELVKEGKISESTA QNYAHLSIAGLVGSIDNDFCG
Bovine EWGSLLEELVSEGKISEGTA QTYSHLNIAGLVGSIDNDFCG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 780 ATP-dependent 6-phosphofructokinase, liver type
2 – 390 N-terminal catalytic PFK domain 1
166 – 166 Proton acceptor
The primary structure of human liver type phosphofructokinase and its comparison with other types of PFK.
Levanon D.; Danciger E.; Dafni N.; Bernstein Y.; Elson A.; Moens W.; Brandeis M.; Groner Y.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT TRP-151;
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