Variant position: 120 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 227 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VGCTG-----KVIGIDHIKELVDDS VNNVRKD---DPTLLS---SGRVQLVV
Mouse VGNSG-----KVIGIDHIKELVDDS ITNVKKD---DPMLLS
Rat VGHSG-----KVIGIDHIKELVDDS ITNVKKD---DPMLLS
Pig VGPSG-----KVIGIDHIKELVDDS INNVRKD---DPMLLS
Bovine VGPSG-----KVIGIDHIKELVDDS INNVRKD---DPMLLS
Chicken VGPKG-----QVVGIDHIKELVDDS INNVKKD---DPTLLS
Zebrafish VGPTG-----KVIGIDHIKELVEDS IANVKKD---DPSLIT
Caenorhabditis elegans VGRNG-----TVVGIEHMPQLVELS EKNIRKH---HSEQLE
Drosophila IKAKGVDADTRIVGIEHQAELVRRS KANLNTD---DRSMLD
Slime mold MGCTG-----RVIGVEHIPELIERS IESIKRL---DSTLLD
Fission yeast VAPNG-----TVKGIEHIPQLVETS KKNLLKDINHDEVLME
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 227 Protein-L-isoaspartate(D-aspartate) O-methyltransferase
113 – 126
Alternative splicing of the human isoaspartyl protein carboxyl methyltransferase RNA leads to the generation of a C-terminal -RDEL sequence in isozyme II.
Maclaren D.C.; Kagan R.M.; Clarke S.;
Biochem. Biophys. Res. Commun. 185:277-283(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); VARIANT ILE-120;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2); VARIANT ILE-120;
Lubec G.; Afjehi-Sadat L.; Chen W.-Q.; Sun Y.;
Cited for: PROTEIN SEQUENCE OF 5-18; 25-37; 82-98; 114-144 AND 179-221; VARIANT ILE-120; IDENTIFICATION BY MASS SPECTROMETRY;
Distinct C-terminal sequences of isozymes I and II of the human erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase.
Ingrosso D.; Kagan R.M.; Clarke S.;
Biochem. Biophys. Res. Commun. 175:351-358(1991)
Cited for: PARTIAL PROTEIN SEQUENCE (ISOFORM 2); VARIANT ILE-120;
Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins.
DeVry C.G.; Clarke S.;
J. Hum. Genet. 44:275-288(1999)
Cited for: VARIANT ILE-120;
Initial characterization of the human central proteome.
Burkard T.R.; Planyavsky M.; Kaupe I.; Breitwieser F.P.; Buerckstuemmer T.; Bennett K.L.; Superti-Furga G.; Colinge J.;
BMC Syst. Biol. 5:17-17(2011)
Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-120; IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];
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