UniProtKB/Swiss-Prot Q05655: Variant p.Phe375Ser

Protein kinase C delta type
Gene: PRKCD
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Variant information Variant position:

375 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant:

LB/B The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Phenylalanine (F) to Serine (S) at position 375 (F375S, p.Phe375Ser). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties:

Change from large size and aromatic (F) to small size and polar (S) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score:

-2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page
Other resources:

Links to websites of interest for the variant.

Variant rs1056998 [ dbSNP | Ensembl ]

Sequence information Variant position:

375 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length:

676 The length of the canonical sequence.
Location on the sequence:

LGKGSFGKVLLGELKGRGEY F AIKALKKDVVLIDDDVECTM The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         LGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTM

                              LGKGSFGKVLLVELKGKKEFFAIKALKKDVVLIDDDVECTM

Mouse                         LGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTM

Rat                           LGKGSFGKVLLAELKGKERYFAIKYLKKDVVLIDDDVECTM

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	1 – 676	Protein kinase C delta type
Chain	330 – 676	Protein kinase C delta type catalytic subunit
Domain	349 – 603	Protein kinase
Binding site	378 – 378
Modified residue	374 – 374	Phosphotyrosine

Literature citations
Molecular and biochemical characterization of a recombinant human PKC-delta family member.
Aris J.P.; Basta P.V.; Holmes W.D.; Ballas L.M.; Moomaw C.; Rankl N.B.; Blobel G.; Loomis C.R.; Burns D.J.;
Biochim. Biophys. Acta 1174:171-181(1993)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS SER-375 AND MET-593;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.