Sequence information
Variant position: 439 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 822 The length of the canonical sequence.
Location on the sequence:
SKFESIRHSIAGIIRSPKSA
L GSSALSDMISISEKPLAEQD
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SKFESIRHSIAGIIRS------------------------PKSAL --------------GSSA-LSDMISISE--------------------------------------------------------------------KPLAEQD
SKFESIRHSIAGIIRS------------------------P
Mouse SKFESIRHSIAGIIKS------------------------P
Rat SKFESIRHSIAGIIKS------------------------P
Drosophila PKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 822
Tyrosine-protein kinase Fer
Modified residue
434 – 434
Phosphoserine
Literature citations
Isolation and sequence analysis of a novel human tyrosine kinase gene.
Hao Q.-L.; Heisterkamp N.; Groffen J.;
Mol. Cell. Biol. 9:1587-1593(1989)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT VAL-439;
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.
Nishisho I.; Nakamura Y.; Miyoshi Y.; Miki Y.; Ando H.; Horii A.; Koyama K.; Utsunomiya J.; Baba S.; Hedge P.; Markham A.; Krush A.J.; Petersen G.M.; Hamilton S.R.; Nilbert M.C.; Levy D.B.; Bryan T.M.; Preisinger A.C.; Smith K.J.; Su L.-K.; Kinzler K.W.; Vogelstein B.;
Science 253:665-669(1991)
Cited for: VARIANT VAL-439;
Patterns of somatic mutation in human cancer genomes.
Greenman C.; Stephens P.; Smith R.; Dalgliesh G.L.; Hunter C.; Bignell G.; Davies H.; Teague J.; Butler A.; Stevens C.; Edkins S.; O'Meara S.; Vastrik I.; Schmidt E.E.; Avis T.; Barthorpe S.; Bhamra G.; Buck G.; Choudhury B.; Clements J.; Cole J.; Dicks E.; Forbes S.; Gray K.; Halliday K.; Harrison R.; Hills K.; Hinton J.; Jenkinson A.; Jones D.; Menzies A.; Mironenko T.; Perry J.; Raine K.; Richardson D.; Shepherd R.; Small A.; Tofts C.; Varian J.; Webb T.; West S.; Widaa S.; Yates A.; Cahill D.P.; Louis D.N.; Goldstraw P.; Nicholson A.G.; Brasseur F.; Looijenga L.; Weber B.L.; Chiew Y.-E.; DeFazio A.; Greaves M.F.; Green A.R.; Campbell P.; Birney E.; Easton D.F.; Chenevix-Trench G.; Tan M.-H.; Khoo S.K.; Teh B.T.; Yuen S.T.; Leung S.Y.; Wooster R.; Futreal P.A.; Stratton M.R.;
Nature 446:153-158(2007)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-128; GLN-404; VAL-412; VAL-439; PRO-443; CYS-460 AND GLN-813;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.