Variant position: 24 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 294 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HGQTCARPMCIPPSYADLGK AARDIFNKG-FGFGLVKLDVKT
Mouse CVPVCPRPMCIPPPYADLGK AARDIFNKG-FGFGLVKLDVK
Rat CVPVCQRPICIPPPYADLGK AARDIFNKG-FGFGLVKLDVK
Pig HGQTCPRPMCIPPSYADLGK AARDIFNKG-FGFGLVKLDVK
Bovine YGQNCARPMCIPPSYADLGK AARDIFNKG-FGFGLVKLDVK
Rabbit HGQTCARPMCIPPSYADLGK AARDIFNKG-FGFGLVKLDVK
Xenopus laevis ---------AVPPSYADLGK SARDIFNKG-YGFGLVKLDVK
Baker's yeast ---------MALRFFNDISR DVNGLFNRDFFHTNPLSLNIS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 294 Voltage-dependent anion-selective channel protein 2
31 – 31 N6-acetyllysine; alternate
31 – 31 N6-succinyllysine; alternate
31 – 31 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.
Blachly-Dyson E.; Zambronicz E.B.; Yu W.H.; Adams V.; McCabe E.R.; Adelman J.P.; Colombini M.; Forte M.A.;
J. Biol. Chem. 268:1835-1841(1993)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3); VARIANT VAL-24;
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