Sequence information
Variant position: 49 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 461 The length of the canonical sequence.
Location on the sequence:
TVFLDHENANKILNRPKRYN
S GKLEEFVQGNLERECMEEKC
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TVFLDHENANKILNRPKRYNS GKLEEFVQGNLERECMEEKC
AVFLDRENATKILSRPKRYNS GKLEEFVRGNLERECIEEKC
Chimpanzee TVFLDHENANKILNRPKRYNS GKLEEFVQGNLERECMEEKC
Mouse AVFLDRENATKILTRPKRYNS GKLEEFVRGNLERECIEERC
Rat AVFLDRENATKILTRPKRYNS GKLEEFVQGNLERECIEERC
Bovine TVFLDRENATKILHRPKRYNS GKLEEFVRGNLERECKEEKC
Cat TVFLDHEDATKVLSRPKRYNS GKLEEFVQGNLERECMEEKC
Chicken TVFIENKEASTVLSRTRRGNS NRLEELIPGNLERECIEEKC
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
47 – 461
Coagulation factor IX
Chain
47 – 191
Coagulation factor IXa light chain
Domain
47 – 92
Gla
Metal binding
47 – 47
Calcium 1; via carbonyl oxygen
Metal binding
48 – 48
Calcium 2
Metal binding
53 – 53
Calcium 1; via 4-carboxyglutamate
Metal binding
53 – 53
Calcium 2; via 4-carboxyglutamate
Metal binding
54 – 54
Calcium 2; via 4-carboxyglutamate
Metal binding
54 – 54
Calcium 3; via 4-carboxyglutamate
Metal binding
61 – 61
Calcium 4; via 4-carboxyglutamate
Metal binding
61 – 61
Magnesium 1; via 4-carboxyglutamate
Metal binding
63 – 63
Calcium 1; via 4-carboxyglutamate
Metal binding
63 – 63
Calcium 2; via 4-carboxyglutamate
Metal binding
63 – 63
Calcium 3; via 4-carboxyglutamate
Metal binding
66 – 66
Calcium 4; via 4-carboxyglutamate
Metal binding
66 – 66
Magnesium 1; via 4-carboxyglutamate
Metal binding
67 – 67
Calcium 1; via 4-carboxyglutamate
Modified residue
53 – 53
4-carboxyglutamate
Modified residue
54 – 54
4-carboxyglutamate
Modified residue
61 – 61
4-carboxyglutamate
Modified residue
63 – 63
4-carboxyglutamate
Modified residue
66 – 66
4-carboxyglutamate
Modified residue
67 – 67
4-carboxyglutamate
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.