Variant position: 357 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 461 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ADKEYTNIFLKFGSGYVSGW GRVFHKGRSALVLQYLRVPLV
Chimpanzee ADKEYTNIFLKFGSGYVSGW GRVFHKGRSALVLQYLRVPLV
Mouse ANREYTNIFLKFGSGYVSGW GKVFNKGRQASILQYLRVPLV
Rat ANKEYTNIFLKFGSGYVSGW GKVFNKGRQASILQYLRVPLV
Bovine ADRDYTNIFLKFGYGYVSGW GKVFNRGRSASILQYLKVPLV
Cat ADREYTNTFLKFGYGYVSGW GKVFNKGRPATILQYLKVPLV
Chicken GSRDFTNNLLSNGPGTVSGW GSMLYRGRSAIVLQVLTVPFV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Factor IX Amagasaki: a new mutation in the catalytic domain resulting in the loss of both coagulant and esterase activities.
Miyata T.; Sakai T.; Sugimoto M.; Naka H.; Yamamoto K.; Yoshioka A.; Fukui H.; Mitsui K.; Kamiya K.; Umeyama H.; Iwanaga S.;
Cited for: VARIANT HEMB GLU-357;
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