Variant position: 436 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 461 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VTEVEGTSFLTGIISWGEEC AMKGKYGIYTKVSRYVNWIKE
Chimpanzee VTEVEGTSFLTGIISWGEEC AMKGKYGIYTKVSRYVNWIKE
Mouse VTEVEGTSFLTGIISWGEEC AMKGKYGIYTKVSRYVNWIKE
Rat VTEVEGTSFLTGIISWGEEC AMKGKYGIYTKVSRYVNWIKE
Bovine VTEVEGTSFLTGIISWGEEC AMKGKYGIYTKVSRYVNWIKE
Cat VTEVEGINFLTGIISWGEEC AMKGKYGIYTKVSRYVNWIKE
Chicken TNSIGETWFLTGVTSWGEEC AKPGKYGIYTKVAKYVKWIRE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Blood clotting factor IX Niigata: substitution of alanine-390 by valine in the catalytic domain.
Sugimoto M.; Miyata T.; Kawabata S.; Yoshioka A.; Fukui H.; Takahashi H.; Iwanaga S.;
J. Biochem. 104:878-880(1988)
Cited for: VARIANT HEMB VAL-436;
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