Variant position: 374 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 810 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SSPVSTEQLAPTAPP-ELTPV VQDCYHGDGQSYRGTSSTTTT
Rhesus macaque SSPVSTEPLDPTAPP-ELTPV VQECYHGDGQSYRGTSSTTT
Mouse SS-ASPDQSDSSVPPEEQTPV VQECYQSDGQSYRGTSSTTI
Rat SS-VSPDQSDSSVLP-EQTPV VQECYQGNGKSYRGTSSTTN
Pig SSTTSTEYLDAPVPP-EQTPV AQDCYRGNGESYRGTSSTTI
Bovine SSPLSTERMDVPVPP-EQTPV PQDCYHGNGQSYRGTSSTTI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 810 Plasminogen
20 – 580 Plasmin heavy chain A
79 – 466 Angiostatin
98 – 580 Plasmin heavy chain A, short form
365 – 365 O-linked (GalNAc...) threonine
Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis.
Ichinose A.; Espling E.S.; Takamatsu J.; Saito H.; Shinmyozu K.; Maruyama I.; Petersen T.E.; Davie E.W.;
Proc. Natl. Acad. Sci. U.S.A. 88:115-119(1991)
Cited for: VARIANTS PLGD PHE-374 AND THR-620;
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