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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P00747: Variant p.Gly751Arg

Plasminogen
Gene: PLG
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Variant information Variant position: help 751 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Glycine (G) to Arginine (R) at position 751 (G751R, p.Gly751Arg). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from glycine (G) to large size and basic (R) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In PLGD; Kanagawa-1; 50% activity. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 751 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 810 The length of the canonical sequence.
Location on the sequence: help RYEFLNGRVQSTELCAGHLA G GTDSCQGDSGGPLVCFEKDK The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         RYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDK

Rhesus macaque                RYEFLNGTVKTTELCAGHLAGGTDSCQGDSGGPLVCFEKDK

Mouse                         RVEYLNNRVKSTELCAGQLAGGVDSCQGDSGGPLVCFEKDK

Rat                           RAEYLNNRVKSTELCAGHLAGGIDSCQGDSGGPLVCFEKDK

Pig                           RYEYLGGKVSPNELCAGHLAGGIDSCQGDSGGPLVCFEKDK

Bovine                        RNEYLDGRVKPTELCAGHLIGGTDSCQGDSGGPLVCFEKDK
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 20 – 810 Plasminogen
Chain 581 – 810 Plasmin light chain B
Domain 581 – 808 Peptidase S1
Active site 760 – 760 Charge relay system
Disulfide bond 699 – 766
Mutagenesis 741 – 741 S -> A. Proteolytically cleaved, but abolishes plasmin activity and cell detachment. Prevents invasion of the mosquito vector midgut by parasite P.falciparum ookinetes.
Beta strand 749 – 751



Literature citations
Plasminogen Kanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R.
Higuchi Y.; Furihata K.; Ueno I.; Ishikawa S.; Okumura N.; Tozuka M.; Sakurai N.;
Br. J. Haematol. 103:867-870(1998)
Cited for: VARIANT PLGD ARG-751;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.