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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04070: Variant p.Gly145Arg

Vitamin K-dependent protein C
Gene: PROC
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Variant information Variant position: help 145 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Glycine (G) to Arginine (R) at position 145 (G145R, p.Gly145Arg). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from glycine (G) to large size and basic (R) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In THPH3. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 145 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 461 The length of the canonical sequence.
Location on the sequence: help GWEGRFCQREVSFLNCSLDN G GCTHYCLEEVGWRRCSCAPG The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 43 – 461 Vitamin K-dependent protein C
Chain 43 – 197 Vitamin K-dependent protein C light chain
Domain 136 – 176 EGF-like 2
Glycosylation 139 – 139 N-linked (GlcNAc...) asparagine
Disulfide bond 140 – 151
Alternative sequence 133 – 133 R -> RGEGERWMLAGGGAGLGPGWGRGTSTSCPRPPLPA. In isoform 2.
Helix 143 – 146



Literature citations
Genetic mutations in ten unrelated American patients with symptomatic type 1 protein C deficiency.
Tsay W.; Greengard J.S.; Montgomery R.R.; McPherson R.A.; Fucci J.C.; Koerper M.A.; Coughlin J.; Griffin J.H.;
Blood Coagul. Fibrinolysis 4:791-796(1993)
Cited for: VARIANTS THPH3 ARG-145; LEU-210; TRP-211; THR-243; LEU-321; MET-340 AND TYR-426;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.