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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04070: Variant p.Thr340Met

Vitamin K-dependent protein C
Gene: PROC
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Variant information Variant position: help 340 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Threonine (T) to Methionine (M) at position 340 (T340M, p.Thr340Met). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and polar (T) to medium size and hydrophobic (M) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In THPH3; Vermont-2. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 340 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 461 The length of the canonical sequence.
Location on the sequence: help LPDSGLAERELNQAGQETLV T GWGYHSSREKEAKRNRTFVL The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 43 – 461 Vitamin K-dependent protein C
Chain 200 – 461 Vitamin K-dependent protein C heavy chain
Domain 212 – 450 Peptidase S1
Modified residue 347 – 347 Phosphoserine; by FAM20C
Glycosylation 355 – 355 N-linked (GlcNAc...) asparagine
Beta strand 336 – 341



Literature citations
Genetic mutations in ten unrelated American patients with symptomatic type 1 protein C deficiency.
Tsay W.; Greengard J.S.; Montgomery R.R.; McPherson R.A.; Fucci J.C.; Koerper M.A.; Coughlin J.; Griffin J.H.;
Blood Coagul. Fibrinolysis 4:791-796(1993)
Cited for: VARIANTS THPH3 ARG-145; LEU-210; TRP-211; THR-243; LEU-321; MET-340 AND TYR-426; Type I protein C deficiency in French Canadians: evidence of a founder effect and association of specific protein C gene mutations with plasma protein C levels.
Couture P.; Demers C.; Morissette J.; Delage R.; Jomphe M.; Couture L.; Simard J.;
Thromb. Haemost. 80:551-556(1998)
Cited for: VARIANTS THPH3 GLN-220 AND MET-340;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.