Variant position: 200 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 622 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ECSIPVCGQ-DQVTVAMTPRS EGSSVNLSPPLEQCVPDRGQQ
Mouse ECSVPVCGQEGRTTVVMTPRS GGSKDNLSPPLGQCLTERGR
Rat ECSIPVCGQEGRTTVKMTPRS RGSKENLSPPLGECLLERGR
Pig ACSIPVCGQ-GRVTAELIPRS GGSTVNVSPPLETCVPERGR
Bovine ECSVPVCGQ-DRVTVEVIPRS GGSTTSQSPLLETCVPDRGR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
44 – 622 Prothrombin
199 – 327 Activation peptide fragment 2
Determination of the amino acid substitution in human prothrombin type 3 (157 Glu leads to Lys) and the localization of a third thrombin cleavage site.
Board P.G.; Shaw D.C.;
Br. J. Haematol. 54:245-254(1983)
Cited for: VARIANT FA2D LYS-200; PARTIAL PROTEIN SEQUENCE;
Quantitative detection of single amino acid polymorphisms by targeted proteomics.
Su Z.D.; Sun L.; Yu D.X.; Li R.X.; Li H.X.; Yu Z.J.; Sheng Q.H.; Lin X.; Zeng R.; Wu J.R.;
J. Mol. Cell Biol. 3:309-315(2011)
Cited for: VARIANTS MET-165; LYS-200; THR-386 AND GLN-532; IDENTIFICATION BY MASS SPECTROMETRY;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.