Sequence information
Variant position: 314 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 622 The length of the canonical sequence.
Location on the sequence:
AVEEETGDGLDEDSDRAIEG
R TATSEYQTFFNPRTFGSGEA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AVEEETGDGLDEDSD--RAIEGR TATSEYQTFFNPRTFGSGEA
Mouse AVGE-------ENYDVDESIAGR TTDAEFHTFFNEKTFGLG
Rat AVGE-------ENHDGDESIAGR TTDAEFHTFFDERTFGLG
Pig PVDEEVGDALGENAD--AAIEGR TTADDFQPFFNEKTFGAG
Bovine PVDGDLGDRLGEDPDPDAAIEGR TSEDHFQPFFNEKTFGAG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
44 – 622
Prothrombin
Peptide
199 – 327
Activation peptide fragment 2
Literature citations
Molecular defect of prothrombin Barcelona. Substitution of cysteine for arginine at residue 273.
Rabiet M.-J.; Furie B.C.; Furie B.;
J. Biol. Chem. 261:15045-15048(1986)
Cited for: VARIANT FA2D CYS-314; PROTEIN SEQUENCE OF 310-327;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.