Variant position: 425 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 622 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AHCLLYPPWDKNFTENDLLV RIGKHSRTRYERNIEKISMLE
Mouse AHCILYPPWDKNFTENDLLV RIGKHSRTRYERNVEKISMLE
Rat AHCILYPPWDKNFTENDLLV RIGKHSRTRYERNVEKISMLE
Pig AHCLLYPPWDKNFTENDLLV RIGKHSRTRYERNIEKISMLE
Bovine AHCLLYPPWDKNFTVDDLLV RIGKHSRTRYERKVEKISMLD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
44 – 622 Prothrombin
364 – 622 Thrombin heavy chain
364 – 618 Peptidase S1
406 – 406 Charge relay system
416 – 416 N-linked (GlcNAc...) (complex) asparagine
336 – 482 Interchain (between light and heavy chains)
422 – 427
Identification of the primary structural defect in the dysthrombin thrombin Quick I: substitution of cysteine for arginine-382.
Henriksen R.A.; Mann K.G.;
Cited for: VARIANT FA2D CYS-425; PARTIAL PROTEIN SEQUENCE;
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