Sequence information
Variant position: 431 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 622 The length of the canonical sequence.
Location on the sequence:
PPWDKNFTENDLLVRIGKHS
R TRYERNIEKISMLEKIYIHP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PPWDKNFTENDLLVRIGKHSR TRYERNIEKISMLEKIYIHP
Mouse PPWDKNFTENDLLVRIGKHSR TRYERNVEKISMLEKIYVHP
Rat PPWDKNFTENDLLVRIGKHSR TRYERNVEKISMLEKIYIHP
Pig PPWDKNFTENDLLVRIGKHSR TRYERNIEKISMLEKIYIHP
Bovine PPWDKNFTVDDLLVRIGKHSR TRYERKVEKISMLDKIYIHP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
44 – 622
Prothrombin
Chain
364 – 622
Thrombin heavy chain
Domain
364 – 618
Peptidase S1
Glycosylation
416 – 416
N-linked (GlcNAc...) (complex) asparagine
Disulfide bond
336 – 482
Interchain (between light and heavy chains)
Beta strand
430 – 433
Literature citations
Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337-->Thr and Arg-388-->His).
Morishita E.; Saito M.; Kumabashiri I.; Asakura H.; Matsuda T.; Yamaguchi K.;
Blood 80:2275-2280(1992)
Cited for: VARIANTS FA2D THR-380 AND HIS-431;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.