Variant position: 431 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 622 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PPWDKNFTENDLLVRIGKHS RTRYERNIEKISMLEKIYIHP
Mouse PPWDKNFTENDLLVRIGKHS RTRYERNVEKISMLEKIYVHP
Rat PPWDKNFTENDLLVRIGKHS RTRYERNVEKISMLEKIYIHP
Pig PPWDKNFTENDLLVRIGKHS RTRYERNIEKISMLEKIYIHP
Bovine PPWDKNFTVDDLLVRIGKHS RTRYERKVEKISMLDKIYIHP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
44 – 622 Prothrombin
364 – 622 Thrombin heavy chain
364 – 618 Peptidase S1
416 – 416 N-linked (GlcNAc...) (complex) asparagine
336 – 482 Interchain (between light and heavy chains)
430 – 433
Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337-->Thr and Arg-388-->His).
Morishita E.; Saito M.; Kumabashiri I.; Asakura H.; Matsuda T.; Yamaguchi K.;
Cited for: VARIANTS FA2D THR-380 AND HIS-431;
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