Variant position: 601 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 622 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RWYQMGIVSWGEGCDRDGKY GFYTHVFRLKKWIQKVIDQFG
Mouse RWYQMGIVSWGEGCDRKGKY GFYTHVFRLKRWIQKVIDQFG
Rat RWYQMGIVSWGEGCDRNGKY GFYTHVFRLKRWMQKVIDQHR
Pig RWYQMGIVSWGEGCDRDGKY GFYTHVFRLKKWMQKVIDRFG
Bovine RWYQMGIVSWGEGCDRDGKY GFYTHVFRLKKWIQKVIDRLG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Substitution of valine for glycine-558 in the congenital dysthrombin thrombin Quick II alters primary substrate specificity.
Henriksen R.A.; Mann K.G.;
Cited for: VARIANT FA2D VAL-601; PARTIAL PROTEIN SEQUENCE;
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