Sequence information
Variant position: 601 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 622 The length of the canonical sequence.
Location on the sequence:
RWYQMGIVSWGEGCDRDGKY
G FYTHVFRLKKWIQKVIDQFG
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RWYQMGIVSWGEGCDRDGKYG FYTHVFRLKKWIQKVIDQFG
Mouse RWYQMGIVSWGEGCDRKGKYG FYTHVFRLKRWIQKVIDQFG
Rat RWYQMGIVSWGEGCDRNGKYG FYTHVFRLKRWMQKVIDQHR
Pig RWYQMGIVSWGEGCDRDGKYG FYTHVFRLKKWMQKVIDRFG
Bovine RWYQMGIVSWGEGCDRDGKYG FYTHVFRLKKWIQKVIDRLG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Literature citations
Substitution of valine for glycine-558 in the congenital dysthrombin thrombin Quick II alters primary substrate specificity.
Henriksen R.A.; Mann K.G.;
Biochemistry 28:2078-2082(1989)
Cited for: VARIANT FA2D VAL-601; PARTIAL PROTEIN SEQUENCE;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.