Variant position: 243 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 967 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human CFDEPAMKAEFNITLIHPKD LTALSNMLPKGPSTPLPEDPN
Mouse CFDEPAMKAMFNITLIYPNN LIALSNMLPK-ESKPYPEDPS
Rat CFDEPAMKASFNITLIHPNN LTALSNMLPK-DSRTLQEDPS
Pig CFDEPAMKATFNITLIHPNN LTALSNMPPKGSSTPLAEDPN
Bovine CFDEPAMKATFNITLIHPKD LTALSNMPPKGPSVPFDGDSN
Rabbit CFDEPAMKATFNITPIHPRD YTALSNMLPR-SSTALPEDPN
Cat CFDEPAMKATFNITIIHPNN LVALSNMLPRGPSVPFGEDPT
Chicken CFDEPAMKAVFTVTMIHPSD HTAISNMPVHSTYQLQMDGQS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 967 Aminopeptidase N
33 – 967 Extracellular
69 – 967 Metalloprotease
234 – 234 N-linked (GlcNAc...) asparagine
243 – 249
Identification of point mutations in the aminopeptidase N gene by SSCP analysis and sequencing.
Lendeckel U.; Wex T.; Arndt M.; Frank K.; Franke A.; Ansorge S.;
Hum. Mutat. Suppl. 1:S158-S160(1998)
Cited for: VARIANTS TYR-242 AND PRO-243;
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