Variant position: 132 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 218 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GDIKVIGGDDLS-------TLTGKNVL IVEDIIDTGKTMQTLLSLVRQ
Chimpanzee GDTKVIGGDDLS-------TLTGKNVL IVEDIIDTGKTMQT
Mouse GDIKVIGGDDLS-------TLTGKNVL IVEDIIDTGKTMQT
Rat GDIKVIGGDDLS-------TLTGKNVL IVEDIIDTGKTMQT
Pig GDIKVIGGDDLS-------TLTGKNVL IVEDIIDTGKTMQT
Bovine GDIKVIGGDDLS-------TLTGKNVL IVEDIIDTGKTMQT
Chicken GDIKVIGGDDLS-------TLTGKNVL IVEDIIDTGKTMKT
Slime mold SGVIRIMMDLRT-------SIEGKDVL IIEDIVDSGLTLKH
Baker's yeast VGVKVSRTQWIDYEQCKL-DLVGKNVL IVDEVDDTRTTLHY
Fission yeast PGLEVKRTQWLDFSTLGMVDLVGKNIL IVDEVDDTRTTLHY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 218 Hypoxanthine-guanine phosphoribosyltransferase
138 – 138 Proton acceptor
142 – 142 Phosphothreonine
115 – 115 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
115 – 115 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
128 – 140
Identification of a single nucleotide change in a mutant gene for hypoxanthine-guanine phosphoribosyltransferase (HPRT Ann Arbor).
Fujimori S.; Hidaka Y.; Davidson B.L.; Palella T.D.; Kelley W.N.;
Hum. Genet. 79:39-43(1988)
Cited for: VARIANT GOUT-HPRT MET-132;
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