Variant position: 135 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 218 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KVIGGDDLS-------TLTGKNVLIVE DIIDTGKTMQTLLSLVRQYNP
Chimpanzee KVIGGDDLS-------TLTGKNVLIVE DIIDTGKTMQTLLS
Mouse KVIGGDDLS-------TLTGKNVLIVE DIIDTGKTMQTLLS
Rat KVIGGDDLS-------TLTGKNVLIVE DIIDTGKTMQTLLS
Pig KVIGGDDLS-------TLTGKNVLIVE DIIDTGKTMQTLLS
Bovine KVIGGDDLS-------TLTGKNVLIVE DIIDTGKTMQTLLA
Chicken KVIGGDDLS-------TLTGKNVLIVE DIIDTGKTMKTLLS
Slime mold IRIMMDLRT-------SIEGKDVLIIE DIVDSGLTLKHLME
Baker's yeast KVSRTQWIDYEQCKL-DLVGKNVLIVD EVDDTRTTLHYALS
Fission yeast EVKRTQWLDFSTLGMVDLVGKNILIVD EVDDTRTTLHYALR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 218 Hypoxanthine-guanine phosphoribosyltransferase
134 – 142 GMP
138 – 138 Proton acceptor
142 – 142 Phosphothreonine
115 – 115 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
115 – 115 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
128 – 140
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.