Sequence information
Variant position: 61 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 189 The length of the canonical sequence.
Location on the sequence:
RKQVVIDGETCLLDILDTAG
Q EEYSAMRDQYMRTGEGFLCV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RKQVVIDGETCLLDILDTAGQ EEYSAMRDQYMRTGEGFLCV
Mouse RKQVVIDGETCLLDILDTAGQ EEYSAMRDQYMRTGEGFLCV
Rat RKQVVIDGETCLLDILDTAGQ EEYSAMRDQYMRTGEGFLCV
Pig RKQVVIDGETCLLDILDTAGQ EEYSAMRDQYMRTGEGFLCV
Chicken RKQVVIDGETCLLDILDTAGQ EEYSAMRDQYMRTGEGFLCV
Xenopus laevis RKQVVIDGETCLLDILDTAGQ EEYSAMRDQYMRTGEGFLCV
Zebrafish RKQVVIDGETCLLDILDTAGQ EEYSAMRDQYMRTGEGFLCV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 186
GTPase NRas
Nucleotide binding
57 – 61
GTP
Literature citations
Detection of a low frequency of activated ras genes in human melanomas using a tumorigenicity assay.
Raybaud F.; Noguchi T.; Marics I.; Adelaide J.; Planche J.; Batoz M.; Aubet C.; de Lapeyriere O.; Birnbaum D.;
Cancer Res. 48:950-953(1988)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-96; VARIANT ARG-61;
RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.
Nikiforova M.N.; Lynch R.A.; Biddinger P.W.; Alexander E.K.; Dorn G.W. II; Tallini G.; Kroll T.G.; Nikiforov Y.E.;
J. Clin. Endocrinol. Metab. 88:2318-2326(2003)
Cited for: INVOLVEMENT IN NMTC2; VARIANT NMTC2 ARG-61;
Pharmacological targeting of STK19 inhibits oncogenic NRAS-driven melanomagenesis.
Yin C.; Zhu B.; Zhang T.; Liu T.; Chen S.; Liu Y.; Li X.; Miao X.; Li S.; Mi X.; Zhang J.; Li L.; Wei G.; Xu Z.X.; Gao X.; Huang C.; Wei Z.; Goding C.R.; Wang P.; Deng X.; Cui R.;
Cell 176:1113-1127(2019)
Cited for: FUNCTION; SUBCELLULAR LOCATION; PHOSPHORYLATION AT SER-89; MUTAGENESIS OF SER-89; VARIANT ARG-61; CHARACTERIZATION OF VARIANT ARG-61;
Genotypic and gene expression studies in congenital melanocytic nevi: insight into initial steps of melanotumorigenesis.
Dessars B.; De Raeve L.E.; Morandini R.; Lefort A.; El Housni H.; Ghanem G.E.; Van den Eynde B.J.; Ma W.; Roseeuw D.; Vassart G.; Libert F.; Heimann P.;
J. Invest. Dermatol. 129:139-147(2009)
Cited for: VARIANTS CMNS ARG-13 AND ARG-61;
Keratinocytic epidermal nevi are associated with mosaic RAS mutations.
Hafner C.; Toll A.; Gantner S.; Mauerer A.; Lurkin I.; Acquadro F.; Fernandez-Casado A.; Zwarthoff E.C.; Dietmaier W.; Baselga E.; Parera E.; Vicente A.; Casanova A.; Cigudosa J.; Mentzel T.; Pujol R.M.; Landthaler M.; Real F.X.;
J. Med. Genet. 49:249-253(2012)
Cited for: VARIANTS KNEN ASP-12; LEU-34 AND ARG-61;
Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS.
Kinsler V.A.; Thomas A.C.; Ishida M.; Bulstrode N.W.; Loughlin S.; Hing S.; Chalker J.; McKenzie K.; Abu-Amero S.; Slater O.; Chanudet E.; Palmer R.; Morrogh D.; Stanier P.; Healy E.; Sebire N.J.; Moore G.E.;
J. Invest. Dermatol. 133:2229-2236(2013)
Cited for: VARIANTS CMNS ARG-61 AND LYS-61; VARIANTS NCMS ARG-61 AND LYS-61;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.