Variant position: 75 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 122 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HARGNYDAAKRGPGGVWAAE AISDARENIQRFFGHGAEDSL
Mouse HARGNYDAAQRGPGGVWAAE KISDGREAFQEFFGRGHEDTI
Rabbit HARGNYDAAQRGPGGVWAAK VISDAREDLQRLMGHGAEDSM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
19 – 122 Serum amyloid A-1 protein
19 – 94 Amyloid protein A
20 – 122 Serum amyloid protein A(2-104)
20 – 121 Serum amyloid protein A(2-103)
20 – 120 Serum amyloid protein A(2-102)
21 – 122 Serum amyloid protein A(3-104)
22 – 119 Serum amyloid protein A(4-101)
65 – 65 R -> A. Reduces affinity for heparin; when associated with A-33 and A-37.
80 – 80 R -> A. Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-18 and A-89.
89 – 89 H -> A. Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-18 and A-80.
67 – 86
Heterogeneity of human serum amyloid A protein. Five different variants from one individual demonstrated by cDNA sequence analysis.
Steinkasserer A.; Weiss E.H.; Schwaeble W.; Linke R.P.;
Biochem. J. 268:187-193(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-122; VARIANTS VAL-75 AND ASN-78;
Identification of two novel amyloid A protein subsets coexisting in an individual patient of AA-amyloidosis.
Baba S.; Takahashi T.; Kasama T.; Shirasawa H.;
Biochim. Biophys. Acta 1180:195-200(1992)
Cited for: PROTEIN SEQUENCE OF 19-94; MASS SPECTROMETRY; DISEASE; VARIANTS ALA-70; VAL-75 AND ASN-78; ALLELE SAA1.3;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.