Sequence information
Variant position: 90 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 122 The length of the canonical sequence.
Location on the sequence:
VWAAEAISDARENIQRFFGH
G AEDSLADQAANEWGRSGKDP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VWAAEAISDARENIQRFFGHG AEDSLADQAANEWGRSGKDP
Mouse VWAAEKISDGREAFQEFFGRG HEDTIADQEANRHGRSGKDP
Rabbit VWAAKVISDAREDLQRLMGHG AEDSMADQAANEWGRSGKDP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
19 – 122
Serum amyloid A-1 protein
Chain
19 – 94
Amyloid protein A
Chain
20 – 122
Serum amyloid protein A(2-104)
Chain
20 – 121
Serum amyloid protein A(2-103)
Chain
20 – 120
Serum amyloid protein A(2-102)
Chain
21 – 122
Serum amyloid protein A(3-104)
Chain
22 – 119
Serum amyloid protein A(4-101)
Modified residue
101 – 101
N4,N4-dimethylasparagine
Mutagenesis
80 – 80
R -> A. Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-18 and A-89.
Mutagenesis
89 – 89
H -> A. Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-18 and A-80.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.