Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases.
Dementiev A.; Simonovic M.; Volz K.; Gettins P.G.;
J. Biol. Chem. 278:37881-37887(2003)
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 26-418 OF VARIANT PITTSBURGH ARG-382;
Mutation of antitrypsin to antithrombin. Alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder.
Owen M.C.; Brennan S.O.; Lewis J.H.; Carrell R.W.;
N. Engl. J. Med. 309:694-698(1983)
Cited for: VARIANT PITTSBURGH ARG-382;
The M358R variant of alpha(1)-proteinase inhibitor inhibits coagulation factor VIIa.
Sheffield W.P.; Bhakta V.;
Biochem. Biophys. Res. Commun. 470:710-713(2016)
Cited for: CHARACTERIZATION OF VARIANT PITTSBURGH ARG-382;
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