Variant position: 450 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1531 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VKHNRIKGIPKLDDANDAGG RNSTECTLILTEGDSAKTLAV
Mouse VKHTKIKGIPKLDDANDAGS RNSTECTLILTEGDSAKTLAV
Rat VKHNRIKGIPKLDDANDAGS RNSAECTLILTEGDSAKTLAV
Pig VKHNRIKGIPKLDDANDAGG RNSTECTLILTEGDSAKTLAV
Chicken VKHTKIKGVPKLDDANDAGS KNSIDCTLILTEGDSAKTLAV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1531 DNA topoisomerase 2-alpha
461 – 461 Magnesium 1; catalytic
440 – 440 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
466 – 466 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
461 – 461 E -> AC. Impairs bending of target DNA. Strongly reduced DNA cleavage.
Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.
Bugg B.Y.; Danks M.K.; Beck W.T.; Suttle D.P.;
Proc. Natl. Acad. Sci. U.S.A. 88:7654-7658(1991)
Cited for: VARIANT TENIPOSIDE-RESISTANT GLN-450;
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