Variant position: 487 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1531 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TLAVSGLGVVGRDKYGVFPL RGKILNVREASHKQIMENAEI
Mouse TLAVSGLGVVGRDKYGVFPL RGKILNVREASHKQIMENAEI
Rat TLAVSGLGVVGRDKYGVFPL RGKILNVREASHKQIMENAEI
Pig TLAVSGLGVVGRDKYGVFPL RGKILNVREASHKQIMENAEI
Chicken TLAVSGLGVVGRDKYGVFPL RGKMLNVREASHKQIMENAEI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1531 DNA topoisomerase 2-alpha
455 – 572 Toprim
489 – 489 Interaction with DNA
492 – 492 Interaction with DNA
480 – 480 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.
Hinds M.; Deisseroth K.; Mayes J.; Altschuler E.; Jansen R.; Ledley F.D.; Zwelling L.A.;
Cancer Res. 51:4729-4731(1991)
Cited for: VARIANT AMSACRINE-RESISTANT LYS-487;
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