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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P60174: Variant p.Gly73Ala

Triosephosphate isomerase
Gene: TPI1
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Variant information Variant position: help 73 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Glycine (G) to Alanine (A) at position 73 (G73A, p.Gly73Ala). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from glycine (G) to small size and hydrophobic (A) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 0 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In TPID. Any additional useful information about the variant.


Sequence information Variant position: help 73 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 249 The length of the canonical sequence.
Location on the sequence: help RQKLDPKIAVAAQNCYKVTN G AFTGEISPGMIKDCGATWVV The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         RQKL-DPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVV

Gorilla                       RQKL-DPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWV

                              RQKL-DAKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWV

Rhesus macaque                RQKL-DPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWV

Chimpanzee                    RQKL-DPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWV

Mouse                         RQKL-DPKIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWV

Rat                           RQKL-DPKIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWV

Pig                           RQKL-DPKIAVAAQNCYKVANGAFTGEIGPGMIKDLGATWV

Bovine                        RQKL-DPKIAVAAQNCYKVANGAFTGEISPGMIKDLGATWV

Rabbit                        RQKL-DPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWV

Chicken                       RQKL-DAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWV

Xenopus laevis                RQKL-DAKIALSAQNCYKVAKGAFTGEISPAMIKDCGATWV

Xenopus tropicalis            RQKL-DAKFAVSAQNCYKVAKGAFTGEISPAMIKDCGATWV

Caenorhabditis elegans        KSKL-KAGVLVAAQNCYKVPKGAFTGEISPAMIKDLGLEWV

Drosophila                    RNLL-PCELGLAGQNAYKVAKGAFTGEISPAMLKDIGADWV

Slime mold                    SNKLDNKKFKVCSQNCYSVAKGAFTGEISANMLVDLGIPYV

Baker's yeast                 VSLVKKPQVTVGAQNAYLKASGAFTGENSVDQIKDVGAKWV

Fission yeast                 RQQV-KKDIGVGAQNVFDKKNGAYTGENSAQSLIDAGITYT
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 249 Triosephosphate isomerase
Modified residue 68 – 68 3'-nitrotyrosine
Modified residue 80 – 80 Phosphoserine
Alternative sequence 1 – 82 Missing. In isoform 3.
Beta strand 69 – 74



Literature citations
Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus.
Watanabe M.; Zingg B.C.; Mohrenweiser H.W.;
Am. J. Hum. Genet. 58:308-316(1996)
Cited for: VARIANTS TPID ALA-73; ASP-105 AND MET-155;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.