Sequence information
Variant position: 73 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 249 The length of the canonical sequence.
Location on the sequence:
RQKLDPKIAVAAQNCYKVTN
G AFTGEISPGMIKDCGATWVV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RQKLD-PKIAVAAQNCYKVTNG AFTGEISPGMIKDCGATWVV
Gorilla RQKLD-PKIAVAAQNCYKVTNG AFTGEISPGMIKDCGATWV
RQKLD-AKIAVAAQNCYKVTNG AFTGEISPGMIKDCGATWV
Rhesus macaque RQKLD-PKIAVAAQNCYKVTNG AFTGEISPGMIKDCGATWV
Chimpanzee RQKLD-PKIAVAAQNCYKVTNG AFTGEISPGMIKDCGATWV
Mouse RQKLD-PKIAVAAQNCYKVTNG AFTGEISPGMIKDLGATWV
Rat RQKLD-PKIAVAAQNCYKVTNG AFTGEISPGMIKDLGATWV
Pig RQKLD-PKIAVAAQNCYKVANG AFTGEIGPGMIKDLGATWV
Bovine RQKLD-PKIAVAAQNCYKVANG AFTGEISPGMIKDLGATWV
Rabbit RQKLD-PKIAVAAQNCYKVTNG AFTGEISPGMIKDCGATWV
Chicken RQKLD-AKIGVAAQNCYKVPKG AFTGEISPAMIKDIGAAWV
Xenopus laevis RQKLD-AKIALSAQNCYKVAKG AFTGEISPAMIKDCGATWV
Xenopus tropicalis RQKLD-AKFAVSAQNCYKVAKG AFTGEISPAMIKDCGATWV
Caenorhabditis elegans KSKLK-AGVLVAAQNCYKVPKG AFTGEISPAMIKDLGLEWV
Drosophila RNLLP-CELGLAGQNAYKVAKG AFTGEISPAMLKDIGADWV
Slime mold SNKLDNKKFKVCSQNCYSVAKG AFTGEISANMLVDLGIPYV
Baker's yeast VSLVKKPQVTVGAQNAYLKASG AFTGENSVDQIKDVGAKWV
Fission yeast RQQVK-KDIGVGAQNVFDKKNG AYTGENSAQSLIDAGITYT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 249
Triosephosphate isomerase
Modified residue
68 – 68
3'-nitrotyrosine
Modified residue
80 – 80
Phosphoserine
Alternative sequence
1 – 82
Missing. In isoform 3.
Beta strand
69 – 74
Literature citations
Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus.
Watanabe M.; Zingg B.C.; Mohrenweiser H.W.;
Am. J. Hum. Genet. 58:308-316(1996)
Cited for: VARIANTS TPID ALA-73; ASP-105 AND MET-155;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.