Variant position: 73 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 249 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RQKL-DPKIAVAAQNCYKVTN GAFTGEISPGMIKDCGATWVV
Gorilla RQKL-DPKIAVAAQNCYKVTN GAFTGEISPGMIKDCGATWV
Rhesus macaque RQKL-DPKIAVAAQNCYKVTN GAFTGEISPGMIKDCGATWV
Chimpanzee RQKL-DPKIAVAAQNCYKVTN GAFTGEISPGMIKDCGATWV
Mouse RQKL-DPKIAVAAQNCYKVTN GAFTGEISPGMIKDLGATWV
Rat RQKL-DPKIAVAAQNCYKVTN GAFTGEISPGMIKDLGATWV
Pig RQKL-DPKIAVAAQNCYKVAN GAFTGEIGPGMIKDLGATWV
Bovine RQKL-DPKIAVAAQNCYKVAN GAFTGEISPGMIKDLGATWV
Rabbit RQKL-DPKIAVAAQNCYKVTN GAFTGEISPGMIKDCGATWV
Chicken RQKL-DAKIGVAAQNCYKVPK GAFTGEISPAMIKDIGAAWV
Xenopus laevis RQKL-DAKIALSAQNCYKVAK GAFTGEISPAMIKDCGATWV
Xenopus tropicalis RQKL-DAKFAVSAQNCYKVAK GAFTGEISPAMIKDCGATWV
Caenorhabditis elegans KSKL-KAGVLVAAQNCYKVPK GAFTGEISPAMIKDLGLEWV
Drosophila RNLL-PCELGLAGQNAYKVAK GAFTGEISPAMLKDIGADWV
Slime mold SNKLDNKKFKVCSQNCYSVAK GAFTGEISANMLVDLGIPYV
Baker's yeast VSLVKKPQVTVGAQNAYLKAS GAFTGENSVDQIKDVGAKWV
Fission yeast RQQV-KKDIGVGAQNVFDKKN GAYTGENSAQSLIDAGITYT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 249 Triosephosphate isomerase
68 – 68 3'-nitrotyrosine
80 – 80 Phosphoserine
1 – 82 Missing. In isoform 3.
69 – 74
Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus.
Watanabe M.; Zingg B.C.; Mohrenweiser H.W.;
Am. J. Hum. Genet. 58:308-316(1996)
Cited for: VARIANTS TPID ALA-73; ASP-105 AND MET-155;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.