Variant position: 123 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 249 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FGESDELIGQKVAHALAEGL GVIACIGEKLDEREAGITEKV
Gorilla FGESDELIGQKVAHALAEGL GVIACIGEKLDEREAGITEKV
Rhesus macaque FGESDELIGQKVAHALAEGL GVIACIGEKLDEREAGITEKV
Chimpanzee FGESDELIGQKVAHALAEGL GVIACIGEKLDEREAGITEKV
Mouse FGESDELIGQKVSHALAEGL GVIACIGEKLDEREAGITEKV
Rat FGESDELIGQKVNHALSEGL GVIACIGEKLDEREAGITEKV
Pig FGESDELIGQKVAHALAEGL GVIACIGEKLDEREAGITEKV
Bovine FGESDELIGQKVAHALAEGL GVIACIGEKLDEREAGITEKV
Rabbit FGESDELIGQKVAHALSEGL GVIACIGEKLDEREAGITEKV
Chicken FGESDELIGQKVAHALAEGL GVIACIGEKLDEREAGITEKV
Xenopus laevis FGECDELIGQKVAHALSEGI GVIACIGEKLDQREAGITEKV
Xenopus tropicalis FGESDELIGQKVAHALSENV GVIGCIGEKLDQREAGITEKV
Caenorhabditis elegans FGESDALIAEKTVHALEAGI KVVFCIGEKLEEREAGHTKDV
Drosophila FGESDALIAEKAEHALAEGL KVIACIGETLEEREAGKTNEV
Slime mold FSESSELITKKTKYAISLGL TVILCLGELLADRKSNNTEHI
Baker's yeast FHEDDKFIADKTKFALGQGV GVILCIGETLEEKKAGKTLDV
Fission yeast FKESDEFVADKTKFALEQGL TVVACIGETLAEREANETINV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 249 Triosephosphate isomerase
106 – 106 Phosphoserine
142 – 142 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
123 – 128
Human triosephosphate isomerase: substitution of Arg for Gly at position 122 in a thermolabile electromorph variant, TPI-Manchester.
Perry B.A.; Mohrenweiser H.W.;
Hum. Genet. 88:634-638(1992)
Cited for: VARIANT MANCHESTER ARG-123;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.