Variant position: 192 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 286 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human REAGITEKVVFEQTKVIAD-N VKDWSKVVLAYEPVWAIGTGK
Gorilla REAGITEKVVFEQTKVITD-N VKDWSKVVLAYEPVWAIGTG
Rhesus macaque REAGITEKVVFEQTKVIAD-N VKDWSKVVLAYEPVWAIGTG
Chimpanzee REAGITEKVVFEQTKVIAD-N VKDWSKVVLAYEPVWAIGTG
Mouse REAGITEKVVFEQTKVIAD-N VKDWSKVVLAYEPVWAIGTG
Rat REAGITEKVVFEQTKAIAD-N VKDWCKVVLAYEPVWAIGTG
Pig REAGITEKVVFEQTKVIAD-N VKDWNKVVLAYEPVWAIGTG
Bovine REAGITEKVVFEQTKVIAD-N VKDWSKVVLAYEPVWAIGTG
Rabbit REAGITEKVVFEQTKVIAD-N VKDWSKVVLAYEPVWAIGTG
Chicken REAGITEKVVFEQTKAIAD-N VKDWSKVVLAYEPVWAIGTG
Xenopus laevis REAGITEKVVFEQTKAIAD-N VKDWSKVVLAYEPVWAIGTG
Xenopus tropicalis REAGITEKVVFEQTKAIAD-N VKDWSKVVLAYEPVWAIGTG
Caenorhabditis elegans REAGHTKDVNFRQLQAIVD-K GVSWENIVIAYEPVWAIGTG
Drosophila REAGKTNEVVARQMCAYAQ-K IKDWKNVVVAYEPVWAIGTG
Slime mold RKSNNTEHILSEQLKDFASFT PEEWSKIVIAYEPVWAIGTG
Baker's yeast KKAGKTLDVVERQLNAVLE-E VKDWTNVVVAYEPVWAIGTG
Fission yeast REANETINVVVRQLNAIAD-K VQNWSKIVIAYEPVWAIGTG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 286 Triosephosphate isomerase
203 – 203 Proton acceptor
186 – 186 N6-succinyllysine
193 – 193 N6-acetyllysine; alternate
193 – 193 N6-succinyllysine; alternate
196 – 196 Phosphoserine
210 – 210 Phosphothreonine
179 – 179 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus.
Watanabe M.; Zingg B.C.; Mohrenweiser H.W.;
Am. J. Hum. Genet. 58:308-316(1996)
Cited for: VARIANTS TPID ALA-110; ASP-142 AND MET-192;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.