Variant position: 90 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 147 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SESGELHGLTTEEEFVEGIY KVEIDTKSYWKALGISPFHEH
Chimpanzee SESGELHGLTTEEEFVEGIY KVEIDTKSYWKALGISPFHEH
Mouse AESGELHGLTTDEKFVEGVY RVELDTKSYWKTLGISPFHEF
Rat AESGELHGLTTDEKFTEGVY RVELDTKSYWKALGISPFHEY
Pig SEFGELHGLTTDEKFVEGIY KVELDTKSYWKALGISPFHEY
Bovine SESGELHGLTTEDKFVEGLY KVELDTKSYWKSLGISPFHEF
Rabbit SKTGELHGLTTSEKFVEGVY KVELDTKSYWKALGISPFHEY
Sheep SDSGELHGLTTEDKFVEGLY KVELDTKSYWKSLGISPFHEY
Chicken TEFGEIHELTTEEQFVEGVY RVEFDTSSYWKGLGLSPFHEY
Xenopus laevis TELGEIHNLTTDEQFTEGVY KIEFATKAFWGKLGLSPFHEY
Xenopus tropicalis TELGEIHNIITDEQFTEGVY KIEFATKTFWRKLGLSPFHEY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
21 – 147 Transthyretin
74 – 74 Thyroid hormones
72 – 72 Phosphoserine
107 – 107 F -> M. Loss of tetramerization; when associated with M-130.
86 – 93
Familial amyloidotic polyneuropathy presenting with carpal tunnel syndrome and a new transthyretin mutation, asparagine 70.
Izumoto S.; Younger D.; Hays A.P.; Martone R.L.; Smith R.T.; Herbert J.;
Cited for: VARIANT AMYL-TTR ASN-90;
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