Variant position: 104 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 147 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FVEGIYKVEIDTKSYWKALG ISPFHEHAEVVFTANDSGPRR
Chimpanzee FVEGIYKVEIDTKSYWKALG ISPFHEHAEVVFTANDSGPRR
Mouse FVEGVYRVELDTKSYWKTLG ISPFHEFADVVFTANDSGHRH
Rat FTEGVYRVELDTKSYWKALG ISPFHEYAEVVFTANDSGHRH
Pig FVEGIYKVELDTKSYWKALG ISPFHEYAEVVFTANDSGRRH
Bovine FVEGLYKVELDTKSYWKSLG ISPFHEFAEVVFTANDSGPRH
Rabbit FVEGVYKVELDTKSYWKALG ISPFHEYAEVVFTANDSGHRS
Sheep FVEGLYKVELDTKSYWKSLG ISPFHEYAEVVFTANDSGLRH
Chicken FVEGVYRVEFDTSSYWKGLG LSPFHEYADVVFTANDSGHRH
Xenopus laevis FTEGVYKIEFATKAFWGKLG LSPFHEYVDVVFTANDAGHRH
Xenopus tropicalis FTEGVYKIEFATKTFWRKLG LSPFHEYVDVVFSANDAGHRH
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
21 – 147 Transthyretin
118 – 118 N-linked (GlcNAc...) asparagine
107 – 107 F -> M. Loss of tetramerization; when associated with M-130.
Genetic microheterogeneity of human transthyretin detected by IEF.
Altland K.; Benson M.D.; Costello C.E.; Ferlini A.; Hazenberg B.P.C.; Hund E.; Kristen A.V.; Linke R.P.; Merlini G.; Salvi F.; Saraiva M.J.; Singer R.; Skinner M.; Winter P.;
Cited for: VARIANTS AMYL-TTR PRO-32; ILE-40; SER-44; ALA-50; MET-50; LEU-53; VAL-53; PRO-56; THR-65; ALA-67; ALA-69; ILE-69; ALA-80; LEU-84; LEU-88; ALA-91; TYR-97; PHE-98; SER-104; ASN-104; THR-104; ALA-114; GLY-117; ASN-126; MET-127; VAL-127; MET-131 AND ILE-142; VARIANTS ILE-33; SER-121 AND THR-129; VARIANT CHICAGO MET-139;
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