Variant position: 136 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 147 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TANDSGPRRYTIAALLSPYS YSTTAVVTNPKE---
Chimpanzee TANDSGPRRYTIAALLSPYS YSTTAVVTIPKE
Mouse TANDSGHRHYTIAALLSPYS YSTTAVVSNPQN
Rat TANDSGHRHYTIAALLSPYS YSTTAVVSNPQN
Pig TANDSGRRHYTIAALLSPYS YSTTALVSSPKE
Bovine TANDSGPRHYTIAALLSPYS YSTTALVSSPKA
Rabbit TANDSGHRSYTIAALLSPFS YSTTAVVSNPQE
Sheep TANDSGLRHYTIAALLSPYS YSTTALVSSPKE
Chicken TANDSGHRHYTIAALLSPFS YSTTAVVSDPQE
Xenopus laevis TANDAGHRHYTIAVLLTPYS FSSTAIVSEPHD
Xenopus tropicalis SANDAGHRHYTIAVLLTPYS ISSTAVVSEPHD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
21 – 147 Transthyretin
135 – 139 Thyroid hormone binding
118 – 118 N-linked (GlcNAc...) asparagine
130 – 130 L -> M. Loss of tetramerization; when associated with M-107.
135 – 143
New transthyretin variants Ser 91 and Ser 116 associated with familial amyloidotic polyneuropathy.
Misrahi A.M.; Plante V.; Lalu T.; Serre I.; Adams D.; Lacroix D.C.; Said G.;
Hum. Mutat. 12:71-71(1998)
Cited for: VARIANTS AMYL-TTR SER-111 AND SER-136;
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