Variant position: 273 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 449 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GSSSSVKWTEGQSNHSTGYE SDNHTTPIL--CGAQYRIHTHGV
Mouse GSSSSVKWTEGQSNHGIGYE SENHTAPIL--CGAQYRIHTH
Rat GSSSSVKWTEGQSNHGTGYE SENHTTPIL--CGAQYRIHTH
Pig GTSSSMKWTEGQSNHGAGYE SDSHATPIL--CGAQYRIHTH
Xenopus tropicalis -------------SHGTSYE NDSHSTPMLYSCGGQYRIHTH
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 449 Wilms tumor protein
The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma.
Park S.; Schalling M.; Bernard A.; Maheswaran S.; Shipley G.C.; Roberts D.; Fletcher J.; Shipman R.; Rheinwald J.; Demetri G.; Griffin J.; Minden M.; Housman D.E.; Haber D.A.;
Nat. Genet. 4:415-420(1993)
Cited for: VARIANT GLY-273; INVOLVEMENT IN MESOM;
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