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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P15313: Variant p.Leu81Pro

V-type proton ATPase subunit B, kidney isoform
Gene: ATP6V1B1
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Variant information Variant position: help 81 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Leucine (L) to Proline (P) at position 81 (L81P, p.Leu81Pro). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic. The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 81 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 513 The length of the canonical sequence.
Location on the sequence: help QYAEIVHFTLPDGTQRSGQV L EVAGTKAIVQVFEGTSGIDA The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         QYAEIVHFTLPDGTQRSGQVLEVAGTKAIVQVFEGTSGIDA

Mouse                         QYAEIVNFTLPDGTQRSGQVLEVAGTKAIVQVFEGTSGIDS

Bovine                        QYAEIVNFTLPNGTQRSGQVLEVSGTKAIVQVFEGTSGIDA

Caenorhabditis elegans        QFSEIVKITLPDGSKRSGQVLEISKNKAVVQVFEGTSGIDA
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 513 V-type proton ATPase subunit B, kidney isoform



Literature citations
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness.
Karet F.E.; Finberg K.E.; Nelson R.D.; Nayir A.; Mocan H.; Sanjad S.A.; Rodriguez-Soriano J.; Santos F.; Cremers C.W.R.J.; Di Pietro A.; Hoffbrand B.I.; Winiarski J.; Bakkaloglu A.; Ozen S.; Dusunsel R.; Goodyer P.; Hulton S.A.; Wu D.K.; Skvorak A.B.; Morton C.C.; Cunningham M.J.; Jha V.; Lifton R.P.;
Nat. Genet. 21:84-90(1999)
Cited for: VARIANTS DRTA2 PRO-81; TRP-124; ARG-174; PRO-275; GLU-316; ARG-346 AND SER-364; TISSUE SPECIFICITY; Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss.
Stover E.H.; Borthwick K.J.; Bavalia C.; Eady N.; Fritz D.M.; Rungroj N.; Giersch A.B.S.; Morton C.C.; Axon P.R.; Akil I.; Al-Sabban E.A.; Baguley D.M.; Bianca S.; Bakkaloglu A.; Bircan Z.; Chauveau D.; Clermont M.-J.; Guala A.; Hulton S.A.; Kroes H.; Li Volti G.; Mir S.; Mocan H.; Nayir A.; Ozen S.; Rodriguez Soriano J.; Sanjad S.A.; Tasic V.; Taylor C.M.; Topaloglu R.; Smith A.N.; Karet F.E.;
J. Med. Genet. 39:796-803(2002)
Cited for: VARIANTS DRTA2 PRO-81; VAL-123; CYS-157; PRO-275 AND ARG-346; VARIANTS ILE-30 AND LYS-161; Confirmation of the ATP6B1 gene as responsible for distal renal tubular acidosis.
Ruf R.; Rensing C.; Topaloglu R.; Guay-Woodford L.; Klein C.; Vollmer M.; Otto E.; Beekmann F.; Haller M.; Wiedensohler A.; Leumann E.; Antignac C.; Rizzoni G.; Filler G.; Brandis M.; Weber J.L.; Hildebrandt F.;
Pediatr. Nephrol. 18:105-109(2003)
Cited for: VARIANT HIS-465; VARIANTS DRTA2 PRO-81 AND ARG-346; Vacuolar H+ -ATPase B1 subunit mutations that cause inherited distal renal tubular acidosis affect proton pump assembly and trafficking in inner medullary collecting duct cells.
Yang Q.; Li G.; Singh S.K.; Alexander E.A.; Schwartz J.H.;
J. Am. Soc. Nephrol. 17:1858-1866(2006)
Cited for: CHARACTERIZATION OF VARIANTS DRTA2 PRO-81; TRP-124; ARG-174; PRO-275; GLU-316; ARG-346 AND SER-364; FUNCTION; SUBCELLULAR LOCATION;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.