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UniProtKB/Swiss-Prot P07203: Variant p.Pro200Leu

Glutathione peroxidase 1
Gene: GPX1
Variant information

Variant position:  200
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Proline (P) to Leucine (L) at position 200 (P200L, p.Pro200Leu).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Similar physico-chemical property. Both residues are medium size and hydrophobic.
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -3
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.

Sequence information

Variant position:  200
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  203
The length of the canonical sequence.

Location on the sequence:   SRRFQTIDIEPDIEALLSQG  P SCA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         SRRFQTIDIEPDIEALLSQGPSCA-

Chimpanzee                    SRRFQTIDIEPDIEALLSQGPSCA

Mouse                         SRRFRTIDIEPDIETLLSQQSGNS

Rat                           SRRFRTIDIEPDIEALLSKQPSNP

Pig                           SRRFLTIDIEPDIEALLSQEPSSA

Bovine                        SRRFLTIDIEPDIETLLSQGASA-

Rabbit                        SRRFPTIDIEPDIQALLSKGSGGA

Caenorhabditis elegans        GPTTDPKDMEKDIKEALGEKL---

Baker's yeast                 SCMTRPLELCPIIEELLNQPPEEQ

Fission yeast                 SSISKPEHLENDIESVL-------

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

Chain 1 – 203 Glutathione peroxidase 1
Modified residue 197 – 197 Phosphoserine
Modified residue 201 – 201 Phosphoserine
Alternative sequence 99 – 203 Missing. In isoform 2.

Literature citations

NIEHS SNPs program;

Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1.
Forsberg L.; de Faire U.; Morgenstern R.;
Hum. Mutat. 13:294-300(1999)
Cited for: VARIANT LEU-200;

Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients.
Hamanishi T.; Furuta H.; Kato H.; Doi A.; Tamai M.; Shimomura H.; Sakagashira S.; Nishi M.; Sasaki H.; Sanke T.; Nanjo K.;
Diabetes 53:2455-2460(2004)
Cited for: VARIANTS ALA-8 DEL AND LEU-200;

Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.
Ichimura Y.; Habuchi T.; Tsuchiya N.; Wang L.; Oyama C.; Sato K.; Nishiyama H.; Ogawa O.; Kato T.;
J. Urol. 172:728-732(2004)
Cited for: VARIANT LEU-200;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.