Variant position: 200 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 203 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SRRFQTIDIEPDIEALLSQG PSCA-
Chimpanzee SRRFQTIDIEPDIEALLSQG PSCA
Mouse SRRFRTIDIEPDIETLLSQQ SGNS
Rat SRRFRTIDIEPDIEALLSKQ PSNP
Pig SRRFLTIDIEPDIEALLSQE PSSA
Bovine SRRFLTIDIEPDIETLLSQG ASA-
Rabbit SRRFPTIDIEPDIQALLSKG SGGA
Caenorhabditis elegans GPTTDPKDMEKDIKEALGEK L---
Baker's yeast SCMTRPLELCPIIEELLNQP PEEQ
Fission yeast SSISKPEHLENDIESVL--- ----
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 203 Glutathione peroxidase 1
197 – 197 Phosphoserine
201 – 201 Phosphoserine
99 – 203 Missing. In isoform 2.
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1); VARIANTS PRO-5; THR-194 AND LEU-200;
Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1.
Forsberg L.; de Faire U.; Morgenstern R.;
Hum. Mutat. 13:294-300(1999)
Cited for: VARIANT LEU-200;
Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients.
Hamanishi T.; Furuta H.; Kato H.; Doi A.; Tamai M.; Shimomura H.; Sakagashira S.; Nishi M.; Sasaki H.; Sanke T.; Nanjo K.;
Cited for: VARIANTS ALA-8 DEL AND LEU-200;
Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.
Ichimura Y.; Habuchi T.; Tsuchiya N.; Wang L.; Oyama C.; Sato K.; Nishiyama H.; Ogawa O.; Kato T.;
J. Urol. 172:728-732(2004)
Cited for: VARIANT LEU-200;
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