Sequence information
Variant position: 200 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 203 The length of the canonical sequence.
Location on the sequence:
SRRFQTIDIEPDIEALLSQG
P SCA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SRRFQTIDIEPDIEALLSQGP SCA-
Chimpanzee SRRFQTIDIEPDIEALLSQGP SCA
Mouse SRRFRTIDIEPDIETLLSQQS GNS
Rat SRRFRTIDIEPDIEALLSKQP SNP
Pig SRRFLTIDIEPDIEALLSQEP SSA
Bovine SRRFLTIDIEPDIETLLSQGA SA-
Rabbit SRRFPTIDIEPDIQALLSKGS GGA
Caenorhabditis elegans GPTTDPKDMEKDIKEALGEKL ---
Baker's yeast SCMTRPLELCPIIEELLNQPP EEQ
Fission yeast SSISKPEHLENDIESVL---- ---
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 203
Glutathione peroxidase 1
Modified residue
197 – 197
Phosphoserine
Modified residue
201 – 201
Phosphoserine
Alternative sequence
99 – 203
Missing. In isoform 2.
Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1); VARIANTS PRO-5; THR-194 AND LEU-200;
Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1.
Forsberg L.; de Faire U.; Morgenstern R.;
Hum. Mutat. 13:294-300(1999)
Cited for: VARIANT LEU-200;
Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients.
Hamanishi T.; Furuta H.; Kato H.; Doi A.; Tamai M.; Shimomura H.; Sakagashira S.; Nishi M.; Sasaki H.; Sanke T.; Nanjo K.;
Diabetes 53:2455-2460(2004)
Cited for: VARIANTS ALA-8 DEL AND LEU-200;
Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.
Ichimura Y.; Habuchi T.; Tsuchiya N.; Wang L.; Oyama C.; Sato K.; Nishiyama H.; Ogawa O.; Kato T.;
J. Urol. 172:728-732(2004)
Cited for: VARIANT LEU-200;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.