Variant position: 157 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 676 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LIFSVLSTIEQYAALATGTL FWMEIVLVVFFGTEYVVRLWS
Mouse LIFSVLSTIEQYAALATGTL FWMEIVLVVFFGTEYVVRLWS
Rat LIFSVLSTIEQYAALATGTL FWMEIVLVVFFGTEYVVRLWS
Rabbit LIFSVLSTIEQYATLATGTL FWMEIVLVVFFGTEYVVRLWS
Xenopus laevis LIFSVLSTIQQYNNLATETL FWMEIVLVVFFGAEYVVRLWS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 676 Potassium voltage-gated channel subfamily KQT member 1
148 – 168 Helical; Name=Segment S2
157 – 177
High-throughput single-strand conformation polymorphism analysis by automated capillary electrophoresis: robust multiplex analysis and pattern-based identification of allelic variants.
Larsen L.A.; Christiansen M.; Vuust J.; Andersen P.S.;
Hum. Mutat. 13:318-327(1999)
Cited for: VARIANT LQT1 CYS-157;
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