Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q15835: Variant p.Thr298Met

Rhodopsin kinase GRK1
Gene: GRK1
Feedback?
Variant information Variant position: help 298
Type of variant: help LB/B
Residue change: help From Threonine (T) to Methionine (M) at position 298 (T298M, p.Thr298Met).
Physico-chemical properties: help Change from medium size and polar (T) to medium size and hydrophobic (M)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 298
Protein sequence length: help 563
Location on the sequence: help HIYNVNEENPGFPEPRALFY T AQIICGLEHLHQRRIVYRDL
Residue conservation: help 
Human                         HIYNVNEENPG-FPEPRALFYTAQIICGLEHLHQRRIVYRDL

Mouse                         HIYNVDEDNPG-FSEPRAIYYTAQIISGLEHLHQRRIVYRD

Rat                           HIYNVDEENPG-FPEPRAIYYTAQIISGLEHLHQRRIVYRD

Bovine                        HIYNVDEDNPG-FQEPRAIFYTAQIVSGLEHLHQRNIIYRD

Caenorhabditis elegans        HLYNL---MPGGFDEKRVQFYAAEITLGLQHLHSERILYRD
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 560 Rhodopsin kinase GRK1
Domain 190 – 455 Protein kinase
Active site 317 – 317 Proton acceptor



Literature citations
Evaluation of the rhodopsin kinase gene in patients with retinitis pigmentosa.
Yamamoto S.; Khani S.C.; Berson E.L.; Dryja T.P.;
Exp. Eye Res. 65:249-253(1997)
Cited for: VARIANTS GLN-136; MET-298; SER-330; HIS-438; SER-514; THR-522 AND LEU-536;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.