Sequence information
Variant position: 461 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 512 The length of the canonical sequence.
Location on the sequence:
KVLSEKVIIFGMGKRKCIGE
T IARWEVFLFLAILLQRVEFS
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KVLSEKVIIFGMGKRKCIGET IARWEVFLFLAILLQRVEFS
KALSEKVILFGLGKRKCIGET IARLEVFLFLAILLQQVEFS
Rhesus macaque KVLSEKVILFGLGKRKCIGET IARWEVFLFLAILLQRVEFS
Mouse KRLSEKVTLFGLGKRKCIGET IGRSEVFLFLAILLQQIEFK
Rat KHLSEKVILFGLGKRKCIGET IGRLEVFLFLAILLQQMEFN
Rabbit KALTEKVLLFGLGKRKCIGET IGRLEVFLFLATLLQQVEFS
Sheep KVLSEKVIIFGLGKRQCIGEI IARLEVFLFLAILLHQVEFH
Cat KALSEKVILFGLGKRKCIGET IARLEVFLFLAILLQQVEFS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 512
Cytochrome P450 1A1
Metal binding
457 – 457
Iron (heme axial ligand)
Alternative sequence
190 – 512
Missing. In isoform 2.
Alternative sequence
419 – 512
Missing. In isoform 3.
Helix
460 – 477
Literature citations
Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone.
Kisselev P.; Schunck W.H.; Roots I.; Schwarz D.;
Cancer Res. 65:2972-2978(2005)
Cited for: FUNCTION; CATALYTIC ACTIVITY; CHARACTERIZATION OF VARIANT ASN-461 AND VARIANT VAL-462; BIOPHYSICOCHEMICAL PROPERTIES; PATHWAY;
A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.
Cascorbi I.; Brockmoller J.; Roots I.;
Cancer Res. 56:4965-4969(1996)
Cited for: VARIANT ASN-461;
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
Solus J.F.; Arietta B.J.; Harris J.R.; Sexton D.P.; Steward J.Q.; McMunn C.; Ihrie P.; Mehall J.M.; Edwards T.L.; Dawson E.P.;
Pharmacogenomics 5:895-931(2004)
Cited for: VARIANTS ASP-45; THR-78; TRP-93; ARG-173; ASN-461; MET-482 AND ARG-492;
Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
Jiang Z.; Dalton T.P.; Jin L.; Wang B.; Tsuneoka Y.; Shertzer H.G.; Deka R.; Nebert D.W.;
Hum. Mutat. 25:196-206(2005)
Cited for: VARIANTS ASP-45; THR-78; ASN-461 AND VAL-462;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.