Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P05181: Variant p.Arg76His

Cytochrome P450 2E1
Gene: CYP2E1
Feedback?
Variant information Variant position: help 76
Type of variant: help LB/B
Residue change: help From Arginine (R) to Histidine (H) at position 76 (R76H, p.Arg76His).
Physico-chemical properties: help Change from large size and basic (R) to medium size and polar (H)
BLOSUM score: help 0
Variant description: help In allele CYP2E1*2; reduced activity.
Other resources: help


Sequence information Variant position: help 76
Protein sequence length: help 493
Location on the sequence: help SFTRLAQRFGPVFTLYVGSQ R MVVMHGYKAVKEALLDYKDE
Residue conservation: help 
Human                         SFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDE

                              SLAKLAEQYGPVFTLYLGSQRTVVLHGYKAVKEVLLDHKND

Rhesus macaque                SFTRLAQRFGPVFTLYVGSRRVVVVHGYKAVREVLLDHKDE

Mouse                         SLTKLAKRFGPVFTLHLGQRRIVVLHGYKAVKEVLLNHKNE

Rat                           SFTKLAKRFGPVFTLHLGSRRIVVLHGYKAVKEVLLNHKNE

Pig                           SFTMLAERYGPVFTVYLGSRRIVVLHGYKAVKEVLLHYKNE

Bovine                        SFTRLAERYGPVFTLYLGSQRAVVVHGYKPVKEVLLDYKNE

Rabbit                        SFGRLAERFGPVFTVYLGSRRVVVLHGYKAVREMLLNHKNE
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 493 Cytochrome P450 2E1
Beta strand 75 – 80



Literature citations
Genetic polymorphism of human CYP2E1: characterization of two variant alleles.
Hu Y.; Oscarson M.; Johansson I.; Yue Q.Y.; Dahl M.L.; Tabone M.; Arinco S.; Albano E.; Ingelman-Sundberg M.;
Mol. Pharmacol. 51:370-376(1997)
Cited for: VARIANTS HIS-76 AND ILE-389;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.