Variant position: 179 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 493 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RKTQGQPFDPTFLIGCAPCN VIADILFRKHFDYNDEKFLRL
Rhesus macaque RKTQGQPFDPTFLIGCAPCN VIADILFRKHFDYNDEKFLRL
Mouse KKTKGQPFDPTFLIGCAPCN VIADILFNKRFDYDDKKCLEL
Rat KKTKGQPFDPTFLIGCAPCN VIADILFNKRFDYNDKKCLRL
Pig RKTHGQPFDPTFLIGCAPCN VISDILFRQHFDYNDKTCLRL
Bovine RKTQGQPFDPTFVVGFAPYN VISDILFHKRFDYKDQTSLRL
Rabbit RKTQGQPFDPTFVIGCTPFN VIAKILFNDRFDYKDKQALRL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Detection and characterization of novel polymorphisms in the CYP2E1 gene.
Fairbrother K.S.; Grove J.; de Waziers I.; Steimel D.T.; Day C.P.; Crespi C.L.; Daly A.K.;
Cited for: VARIANT CYP2E1*4 ILE-179;
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
Solus J.F.; Arietta B.J.; Harris J.R.; Sexton D.P.; Steward J.Q.; McMunn C.; Ihrie P.; Mehall J.M.; Edwards T.L.; Dawson E.P.;
Cited for: VARIANTS ILE-179 AND LEU-457;
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